MicroRNA predicts cognitive performance in healthy older adults

Gullett, Joseph M.; Chen, Zhaoyi; O’Shea, Andrew; Akbar, Maisha; Bian, Jiang; Rani, Asha; Porges, Eric C.; Foster, Thomas C.; Woods, Adam J.; Modave, François; Cohen, Ronald A.

doi:10.1016/j.neurobiolaging.2020.07.023

Cited by 33 publications

(35 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moving to dementia, MiR-181c-3p isolated from microvesicles from patients with sporadic AD related to crystalized cognition [204,205], the knowledge and skills acquired through education and cultural experiences. MiR-223, in the serum of 84 people with probable AD, strongly, positively correlated with Mini Mental State Exam (MMSE) [156].…”

Section: ) Mirs Associated With Apoptosismentioning

confidence: 99%

A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways

Varma-Doyle

Lukiw

Zhao

et al. 2021

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Cognitive impairment (CI) is a frequent complication affecting people with multiple sclerosis (MS). The causes of CI in MS are not fully understood. Besides MRI measures, few other biomarkers exist to help us predict the development of CI and understand its biology. MicroRNAs (miRs) are relatively stable, non-coding RNA molecules about 22 nucleotides in length that can serve as biomarkers and possible therapeutic targets in several autoimmune and neurodegenerative diseases, including the dementias. In this review, we identify dysregulated miRs in MS that overlap with dysregulated miRs in cognitive disorders and dementia and explore how these overlapping miRs play a role in CI in MS. are known to contribute to various forms of dementia and show abnormal expression in MS. These overlapping miRs are involved in pathways related to apoptosis, neuroinflammation, glutamate toxicity, astrocyte activation, microglial burst activity, synaptic dysfunction, and remyelination. The mechanisms of action suggest that these miRs may be related to CI in MS.From our review, we also delineated miRs that could be neuroprotective in MS, namely miR-23a, miR-219, miR-214, and miR-22.Further studies can help clarify if these miRs are responsible for CI in MS, leading to potential therapeutic targets.

show abstract

Section: ) Mirs Associated With Apoptosismentioning

confidence: 99%

A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways

Varma-Doyle

Lukiw

Zhao

et al. 2021

Journal of the Neurological Sciences

View full text Add to dashboard Cite

show abstract

“…Although previous work has implicated them in similar pathological processes such as brain ischemia ( Casey et al., 2020 ; Moon et al., 2013 ; Han et al., 2018 ) and Alzheimer disease ( Akhter et al., 2018 ; Ansari et al., 2019 ; Rodriguez-Ortiz et al., 2020 ), their physiological functions remain poorly explored. Increasing evidence suggest that both miR-140-5p ( Ambrozkiewicz et al., 2018 ) and miR-181a-5p ( Chandrasekar and Dreyer, 2009 ; Rodriguez-Ortiz et al., 2020 ; Saba et al., 2012 ) play important roles in neurons and are required for proper cognition ( Gullett et al., 2020 ; Xu et al., 2018 ; Zhang et al., 2017 ). Remarkably, modulation of miR-140-5p expression by social context has been already reported in zebra finches ( Shi et al., 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Social Isolation and Enrichment Induce Unique miRNA Signatures in the Prefrontal Cortex and Behavioral Changes in Mice

et al. 2020

View full text Add to dashboard Cite

Summary An extensive body of evidence supports the notion that exposure to an enriched/impoverished environment alters brain functions via epigenetic changes. However, how specific modifications of social environment modulate brain functions remains poorly understood. To address this issue, we investigate the molecular and behavioral consequences of briefly manipulating social settings in young and middle-aged wild-type mice. We observe that, modifications of the social context, only affect the performance in socially related tasks. Social enrichment increases sociability whereas isolation leads to the opposite effect. Our work also pointed out specific miRNA signatures associated to each social environment. These miRNA alterations are reversible and found selectively in the medial prefrontal cortex. Finally, we show that miRNA modifications linked to social enrichment or isolation might target rather different intracellular pathways. Together, these observations suggest that the prefrontal cortex may be a key brain area integrating social information via the modification of precise miRNA networks.

show abstract

“…Non-coding RNAs (ncRNAs), including circular RNAs (circRNAs), long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), are the dominant products of eukaryotic transcription, and function directly at the RNA level [ 11 – 13 ]. NcRNAs not only are involved in cell proliferation, apoptosis, differentiation, metabolism and other physiological processes, but also contribute to the pathogenesis of diseases [ 14 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Functional predication of differentially expressed circRNAs/lncRNAs in the prefrontal cortex of Nrf2-knockout mice

Gao

Zhang

Liu

et al. 2021

Aging

View full text Add to dashboard Cite

In the central nervous system, nuclear factor erythroid-2-related factor 2 (Nrf2) protects neurons from oxidant injury, thereby ameliorating neurodegeneration. We explored the key circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) involved in Nrf2-induced neuroprotection. We used microarrays to examine the circRNAs (DEcircRNAs), lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) differentially expressed between Nrf2 (+/+) and Nrf2 (-/-) mice and identified DEcircRNA/DElncRNA-miRNA-DEmRNA interaction networks. In total, 197 DEcircRNAs, 685 DElncRNAs and 356 DEmRNAs were identified in prefrontal cortical tissues from Nrf2 (-/-) mice. The expression patterns of selected DEcircRNAs (except for mmu_circ_0003404) and DElncRNAs in qRT-PCR analyses were generally consistent with the microarray analysis results. Functional annotation of the DEmRNAs in the DEcircRNA/DElncRNA-miRNA-DEmRNA networks indicated that five non-coding RNAs (mmu_circ_0000233, ENSMUST00000204847, NONMMUT024778, NONMMUT132160 and NONMMUT132168) may contribute to Nrf2 activity, with the help of mmu_circ_0015035 and NONMMUT127961. The results also revealed that four non-coding RNAs (cicRNA.20127, mmu_circ_0012936, ENSMUST00000194077 and NONMMUT109267) may influence glutathione metabolism. Additionally, 44 DEcircRNAs and 7 DElncRNAs were found to possess coding potential. These findings provide clues to the molecular pathways through which Nrf2 protects neurons.

show abstract

MicroRNA predicts cognitive performance in healthy older adults

Cited by 33 publications

References 53 publications

A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways

A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways

Social Isolation and Enrichment Induce Unique miRNA Signatures in the Prefrontal Cortex and Behavioral Changes in Mice

Functional predication of differentially expressed circRNAs/lncRNAs in the prefrontal cortex of Nrf2-knockout mice

Contact Info

Product

Resources

About