MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma

Sakata, Junichi; Sasayama, Takashi; Tanaka, Kazuhiro; Nagashima, Hiroaki; Nakada, Mitsutoshi; Tanaka, Hirotomo; Hashimoto, Naoya; Kagawa, Naoki; Kinoshita, Manabu; Nakamizo, Satoshi; Maeyama, Masao; Nishihara, Masamitsu; Hosoda, Kohkichi; Kohmura, Eiji

doi:10.1007/s11060-019-03113-2

Cited by 15 publications

(16 citation statements)

References 42 publications

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“…( 7 ). It has also been reported recently that stanniocalcin-1 (STC1), a secreted glycoprotein, may act as a novel metastasis/metastatic dissemination-promoting factor regulated by miR-137 in GBM ( 36 ). In addition, it was reported that direct inhibition of SLC1A5 by miR-137 enhances glioma cell oxidative stress and triggers lipid peroxidation, which eventually induces tumor cell death ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

A miR-137-XIAP axis contributes to the sensitivity of TRAIL-induced cell death in glioblastoma

et al. 2022

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Glioblastoma (GBM) is the most lethal primary brain tumor in the central nervous system with limited therapeutic strategies to prolong the survival rate in clinic. TNF-related apoptosis-inducing ligand (TRAIL)-based strategy has been demonstrated to induce cell death in an extensive spectrum of tumor cells, including GBM, while a considerable proportion of malignant cells are resistant to TRAIL-induced apoptosis. MiR-137 is highly expressed in the brain, but significantly decreases with advanced progression of GBM. However, the functional link between miR-137 and TRAIL-induced apoptosis in GBM cells has not been established. Here, GBM cells were transfected with miR-137, and gene expression levels were examined by qRT-PCR and western blot. Apoptotic cells were measured by Annexin-V staining and TUNEL assay. Our data showed that miR-137 sensitizes GBM cells to the TRAIL-mediated apoptosis. Mechanistically, we identified that XIAP is a bona fide target of miR-137, which is essential for miR-137-regulated sensitivity of TRAIL-induced cell death in GBM cells. Finally, in a xenograft model, combined utilization of miR-137 and TRAIL potently suppresses tumor growth in vivo. Collectively, we demonstrate that a miR-137-XIAP axis is required for the sensitivity of TRAIL-induced cell death and shed a light on the avenue for the treatment of GBM.

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Section: Discussionmentioning

confidence: 99%

A miR-137-XIAP axis contributes to the sensitivity of TRAIL-induced cell death in glioblastoma

et al. 2022

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“… 30 Recently, it was reported that stanniocalcin-1 (STC1), a secreted glycoprotein hormone, may act as a novel metastasis/metastatic dissemination-promoting factor regulated by miR-137 in glioblastoma. 56 , 57 STC1 is closely related to the degree of glioma malignancy. The mRNA and protein levels of STC1 in high-grade glioma tissues are much higher than those in low-grade glioma tissues.…”

Section: Main Textmentioning

confidence: 99%

“… 56 miR-137 has a predicted binding site in STC1 mRNA, and the miR-137 analog is involved in downregulating STC1 mRNA expression in glioblastoma cells. 57 Therefore, the inhibitory effect of miR-137 on glioma invasion and metastasis may be partly implemented by suppressing STC1.…”

Section: Main Textmentioning

confidence: 99%

“… 6 Furthermore, miR-137 inhibits glioblastoma stemness through various targets, such as glioma pathogenesis-related protein 1 (GLIPR1) and Musashi-1 (Msi1), which are related to testes-specific vespid and pathogenesis protein 1 (RTVP-1) and STC1. 6 , 57 , 59 For example, miR-137 reduces the transcriptional expression of RTVP-1, while RTVP-1 facilitates the self-renewal of GSCs by enhancing CXXR4. 6 miR-137 is involved in regulating the expression of STC1, whereas the latter enhances the stem-like characteristics of glioblastomacells by activating the NOTCH1-SOX2 signaling pathway.…”

Section: Main Textmentioning

confidence: 99%

“… 6 miR-137 is involved in regulating the expression of STC1, whereas the latter enhances the stem-like characteristics of glioblastomacells by activating the NOTCH1-SOX2 signaling pathway. 57 , 59 Msi1 is a stem-cell protein involved in self-renewal that has the opposite expression pattern and function to miR-137, and these proteins inhibit each other. Msi1 and miR-137 are regulators of molecular conversion between self-renewal and differentiation, and they share 141 target genes related to differentiation, development, and morphogenesis.…”

Section: Main Textmentioning

confidence: 99%

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miR-137: A Novel Therapeutic Target for Human Glioma

Wang

Chen

Zhou

et al. 2020

Molecular Therapy - Nucleic Acids

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MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. In addition, we focus on the identified miR-137 targets and pathways in the occurrence and development of glioma. Finally, future implications for the diagnostic and therapeutic potential of miR-137 in glioma were discussed.

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Identification of testicular cancer immune infiltrates and novel immune cell subtypes

Zhu

Wang

et al. 2023

FEBS Open Bio

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Testicular germ cell tumors (TGCT) are the most common type of testicular cancer, comprising 90%‐95% of cases and representing the most prevalent solid malignancy in young adult men. Immune infiltrates play important regulatory roles in tumors, but their role in TGCT remains unclear. Molecular subtyping is a promising way to provide precisely personalized treatment and avoid unnecessary toxicities. This study investigated immune infiltrates, key biomarkers, and immune subtyping of TGCT. In GSE3218, 24 differentially expressed immune genes (immDEGs) were identified. A new risk signature consisting of six immDEGs was developed using these genes. Individuals in the high‐risk group had poor overall survival (OS) (hazard ratio of 4.61 and P‐value <0.001). We validated the six‐immDEGs risk signature in pure seminoma and mixed TGCT types. Two distinct immune patterns (Cluster 1 and Cluster 2) were identified using the ConsensusClusterPlus, and Cluster 1 possessed an unfavorable OS compared to Cluster 2 (hazard ratio, 2.56; P <0.001). Cluster 1 patients had significantly lower naive B cells, memory B cells, plasma cells, naive CD4 T cells, gamma delta T cells, and activated dendritic cells than Cluster 2 patients. Genes relating to the WNT signaling pathway, TGF‐β signaling pathway, antigen processing and presentation, and NK cell‐mediated cytotoxicity were associated with TGCT. STC1 was elevated in TGCT tissues, and its high expression showed advanced clinicopathological characteristics and poor prognosis of TGCT. Our findings may contribute to increased understanding of the onset and progression of TGCT.

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MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma

Cited by 15 publications

References 42 publications

A miR-137-XIAP axis contributes to the sensitivity of TRAIL-induced cell death in glioblastoma

A miR-137-XIAP axis contributes to the sensitivity of TRAIL-induced cell death in glioblastoma

miR-137: A Novel Therapeutic Target for Human Glioma

Identification of testicular cancer immune infiltrates and novel immune cell subtypes

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