MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review

Manetti, A; Maiese, Aniello; Paolo, Marco Di; Matteis, Alessandra De; Russa, Raffaele La; Turillazzi, Emanuela; Frati, Paola; Fineschi, Vittorio

doi:10.3390/ijms22010321

Cited by 48 publications

(36 citation statements)

References 92 publications

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“…MiRNAs have attracted the attention of researchers in various fields [ 38 , 39 , 40 , 41 ]. They influence many signaling pathways involved in inflammation [ 42 , 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications

et al. 2021

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Wound vitality demonstration is one of the most challenging fields in forensic pathology. In recent years, researchers focused on the application of histological and immunohistochemical staining in this sphere of study. It is based on the detection of inflammation, red cell infiltration, and tissue alterations at the histological examination, all of which are supposedly present in antemortem rather than post-mortem wounds. Nevertheless, some doubts about the reliability of those markers have arisen. Furthermore, the lack of a standardized protocol and the operator dependency of this approach make the proper interpretation of its results difficult. Moreover, a differential miRNAs expression has been demonstrated in antemortem and post-mortem wounds. Herein, a systematic review concerning the current knowledge about the use of miRNAs in lesion vitality evaluation is carried out, to encourage researchers to deepen this peculiar study area. A compendium about the potential miRNAs that may be further investigated as vitality markers is also provided. The aim is to collect all available data about this topic to direct further studies on this field and highlight the future applications of miRNAs in forensic pathology. We found 20 articles and a total of 51 miRNAs that are involved in inflammation and wound healing. Further studies are certainly needed to deepen the role of miRNAs in inflammatory processes in lesioned skin and to evaluate their reliability in distinguishing between antemortem and post-mortem lesions.

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“…MiRNAs have attracted the attention of researchers in various fields [ 38 , 39 , 40 , 41 ]. They influence many signaling pathways involved in inflammation [ 42 , 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications

et al. 2021

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“…miR-144-3p, located in human chromosome 17q11.2 [ 29 ], has been reported to be associated with human myocardial infarction [ 30 ]. Multiple studies have shown that miRNAs play a role in sepsis and sepsis-induced heart damage [ 31 ]. In this study, we confirmed that CASC15 directly targeted miR-144-3p and negatively regulated the expression level of miR-144-3p.…”

Section: Discussionmentioning

confidence: 99%

Aberrant long non-coding RNA cancer susceptibility 15 (CASC15) plays a diagnostic biomarker and regulates inflammatory reaction in neonatal sepsis

Song

et al. 2021

Bioengineered

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Neonatal sepsis (NS) is one of the important causes of neonatal death. There are many studies to confirm the role of long non-coding RNA (lncRNA) in neonatal infectious diseases. This study aimed to explore the level of cancer susceptibility 15 (CASC15) and its effect on inflammatory response in NS. Seventy-nine neonatal pneumonia (NP) patients and 80 NS patients were enrolled in this study. Reverse Transcription-quantitative PCR (RT-qPCR) was used to determine the expression levels of CASC15 and miR-144-3p. Receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic value of CASC15 in NS. RAW264.7 cells were stimulated with LPS to simulate the inflammatory response in NS patients, and the regulation and mechanism of CASC15 on the inflammatory response were explored in this in vitro cell model. Serum CASC15 was upregulated in NS patients, and it had the ability to distinguish NS patients from NP patients. LPS stimulation increased the expression of CASC15 and simultaneously stimulated the secretion of inflammatory cytokines, while the knockdown of CASC15 alleviated the inflammatory response induced by LPS stimulation. Besides, serum miR-144-3p was reduced in NS patients, and luciferase reporter genes showed that miR-144-3p was a direct target of CASC15. Overexpression of CASC15 may promote the inflammatory response of NS by targeted regulating the expression of miR-144-3p, which may provide us with new insights in the treatment of NS.

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“…* p < .05 4 | DISCUSSION miRNAs are implicated in the pathogenesis of sepsis-related cardiac, lung, liver and kidney disorders. 21,22,[31][32][33] This study aimed to ascertain a novel target for the treatment of sepsisinduced ALI. This study revealed that miR-942-5p limited TRIM37 expression and ameliorated LPS-induced ALI in vitro and inflammatory response in A549 cells.…”

Section: Trim37 Overexpression Attenuates the Protective Role Of 942-5p In Lps-treated A549 Cellsmentioning

confidence: 99%

miR‐942‐5p prevents sepsis‐induced acute lung injury via targeting TRIM37

Lü

Zhang

Liu

et al. 2021

Int J Experimental Path

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MicroRNAs (miRNAs) have been demonstrated to play pivotal roles in the pathogenesis of sepsis‐induced acute lung injury (ALI). In this work, we aimed to clarify the potential role and the underlying mechanism of miR‐942‐5p in a lipopolysaccharide (LPS)‐induced A549 cell injury model. The cell injury was evaluated by CCK‐8 assay, flow cytometry and enzyme‐linked immunosorbent assay (ELISA). The expression levels of miR‐942‐5p and tripartite motif‐containing protein 37 (TRIM37) were measured by real‐time PCR and Western blot, and their association was then validated by bioinformatics, luciferase reporter assay and RNA pull‐down assay. We found that the expression of miR‐942‐5p was decreased in LPS‐treated A549 cells. Furthermore, LPS treatment suppressed A549 cell viability, promoted apoptosis and increased the levels of inflammatory cytokines. Conversely, overexpression of miR‐942‐5p increased cell viability, reduced apoptosis and alleviated inflammatory cytokine secretion in the presence of LPS. Moreover, miR‐942‐5p directly targeted TRIM37 by binding to the 3′‐UTR of TRIM37 mRNA. Upregulation of TRIM37 effectively reversed the anti‐apoptotic and anti‐inflammatory effects of miR‐942‐5p in LPS‐induced A549 cells. Our findings suggested that miR‐942‐5p protected against LPS‐induced cell injury through inhibiting apoptosis and inflammation in A549 cells by negatively regulating TRIM37.

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MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review

Cited by 48 publications

References 92 publications

MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications

MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications

Aberrant long non-coding RNA cancer susceptibility 15 (CASC15) plays a diagnostic biomarker and regulates inflammatory reaction in neonatal sepsis

miR‐942‐5p prevents sepsis‐induced acute lung injury via targeting TRIM37

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