MicroRNAs and synapse turnover in Alzheimer’s disease

Dalal, Sarthak; Ramirez-Gomez, Jaime; Sharma, Bhupender; Devara, Davin; Kumar, Subodh

doi:10.1016/j.arr.2024.102377

Ageing Research Reviews

2024

DOI: 10.1016/j.arr.2024.102377

|View full text |Cite

MicroRNAs and synapse turnover in Alzheimer’s disease

Sarthak Dalal,

Jaime Ramirez-Gomez,

Bhupender Sharma

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 133 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The emerging role of exercise in Alzheimer’s disease: Focus on mitochondrial function

Feng,

Li,

Yong

et al. 2024

Ageing Research Reviews

View full text Add to dashboard Cite

The emerging role of exercise in Alzheimer’s disease: Focus on mitochondrial function

Feng,

Li,

Yong

et al. 2024

Ageing Research Reviews

View full text Add to dashboard Cite

Advances in understanding biomarkers and treating neurological diseases – Role of the cerebellar dysfunction and emerging therapies

Sivalingam

2024

Ageing Research Reviews

View full text Add to dashboard Cite

Pathology and Treatments of Alzheimer’s Disease Based on Considering Changes in Brain Energy Metabolism Due to Type 2 Diabetes

Yanai,

Adachi,

Hakoshima

et al. 2024

Molecules

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with cognitive dysfunction, memory decline, and behavioral disturbance, and it is pathologically characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. Although various hypotheses have been proposed to explain the pathogenesis of AD, including the amyloid beta hypothesis, oxidative stress hypothesis, and abnormal phosphorylation of tau proteins, the exact pathogenic mechanisms underlying AD remain largely undefined. Furthermore, effective curative treatments are very limited. Epidemiologic studies provide convincing evidence for a significant association between type 2 diabetes and AD. Here, we showed energy metabolism using glucose, lactate, ketone bodies, and lipids as energy substrates in a normal brain, and changes in such energy metabolism due to type 2 diabetes. We also showed the influences of such altered energy metabolism due to type 2 diabetes on the pathology of AD. Furthermore, we comprehensively searched for risk factors related with type 2 diabetes for AD and showed possible therapeutic interventions based on considering risk factors and altered brain energy metabolism due to type 2 diabetes for the development of AD.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

MicroRNAs and synapse turnover in Alzheimer’s disease

Cited by 3 publications

References 133 publications

The emerging role of exercise in Alzheimer’s disease: Focus on mitochondrial function

The emerging role of exercise in Alzheimer’s disease: Focus on mitochondrial function

Advances in understanding biomarkers and treating neurological diseases – Role of the cerebellar dysfunction and emerging therapies

Pathology and Treatments of Alzheimer’s Disease Based on Considering Changes in Brain Energy Metabolism Due to Type 2 Diabetes

Contact Info

Product

Resources

About