MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination Response

Dias, Tânia R.; Dias, Francisca; Teixeira, Ana Luísa; Sousa, Hugo; Oliveira, J.; Medeiros, Rui

doi:10.3390/cells11152279

“…Since miRNAs play a relevant role in the development and progression of human diseases, they have been proposed as tools to detect and predict neurodegenerative diseases, infections, and cancer. In all of them, the expression levels of specific miRNAs are altered [ 27 , 28 ]. Moreover, variations in the expression of miRNAs could also serve as a tool to predict changes in physiological processes [ 29 ].…”

Section: Mirnas As Possible Diagnosis Prognosis Prevention and Treatm...mentioning

confidence: 99%

microRNAs: Critical Players during Helminth Infections

Rojas-Pirela

¹

,

Andrade-Alviárez

²

,

Quiñones

³

et al. 2022

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MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression post-transcriptionally through their interaction with the 3′ untranslated regions (3′ UTR) of target mRNAs, affecting their stability and/or translation. Therefore, miRNAs regulate biological processes such as signal transduction, cell death, autophagy, metabolism, development, cellular proliferation, and differentiation. Dysregulated expression of microRNAs is associated with infectious diseases, where miRNAs modulate important aspects of the parasite–host interaction. Helminths are parasitic worms that cause various neglected tropical diseases affecting millions worldwide. These parasites have sophisticated mechanisms that give them a surprising immunomodulatory capacity favoring parasite persistence and establishment of infection. In this review, we analyze miRNAs in infections caused by helminths, emphasizing their role in immune regulation and its implication in diagnosis, prognosis, and the development of therapeutic strategies.

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“…With regard to cardiovascular medicine, it is desirable to know specific genetic risk factors for the development of myocarditis during COVID-19 or upon vaccination [112,[165][166][167][168][169][170][226][227][228][229][230][231][232], or for development of long COVID syndromes [191,[233][234][235][236][237][238][239]. Fortunately, SARS-CoV-2 is rather rarely causing severe myocarditis or cardiomyopathies [165][166][167][168][169][170].…”

Section: Cardiovascular Immunobiology Of Covid-19 and Long Covid Synd...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

0

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During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

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“…Of course it needs to be emphasized that the definitive establishment of predictive or differential diagnostic expression profiles requires confirmation by several independent clinical studies. This has been rarely achieved so far [1,2], but the available evidence does suggest significant clinical potential for selected clinical settings [1,2,[110][111][112][113].…”

Section: Novel Nucleic Acid Therapeutics Targeting Conventional Prote...mentioning

confidence: 99%

“…With regard to cardiovascular medicine, it is desirable to know specific genetic risk factors for the development of myocarditis during COVID-19 or upon vaccination [112,[164][165][166][167][168][169][204][205][206][207][208][209], or for development of long COVID syndromes [190,[210][211][212][213].…”

Section: Cardiovascular Immunobiology Of Covid-19 and Long Covid Synd...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

show abstract

MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination Response

Cited by 11 publications

References 99 publications

microRNAs: Critical Players during Helminth Infections

microRNAs: Critical Players during Helminth Infections

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

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