MicroRNAs expression changes coincide with low or high grade of squamous intraepithelial lesion infected by HPV-16

Norouzi, Sara; Farhadi, Ali; Farzadfard, Ehsan; Akbarzade-Jahromi, Mojgan; Ahmadzadeh, Neda; Nasiri, Mahboobeh; Tamaddon, Gholamhossein

doi:10.1016/j.genrep.2021.101186

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…In the case of HSIL patients, miR-16 and miR-34a expression changes resulted irrelevant compared to the HPVnegative control group. However, miR-21 expression significantly increased while miR-143 decreased compared to the HPVnegative group (Norouzi et al, 2021).…”

Section: Hpv and Mirnasmentioning

confidence: 80%

Cervical Cancer, Papillomavirus, and miRNA Dysfunction

Bañuelos-Villegas¹,

Perez-Y-Perez²,

Álvarez-Salas³

2021

Front. Mol. Biosci.

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Cervical cancer is the leading cause of death by cancer in women from developing countries. Persistent infection with high-risk human papillomavirus (HPV) types 16 and 18 is a major risk factor for cervical carcinogenesis. Nevertheless, only a few women with morphologic expression of HPV infection progress into invasive disease suggesting the involvement of other factors in cervical carcinogenesis. MicroRNAs (miRNAs) are conserved small non-coding RNAs that negatively regulate gene expression including genes involved in fundamental biological processes and human cancer. Dysregulation of miRNAs has been widely reported in cervical cancer. This work focuses on reviewing the miRNAs affected during the HPV infection process, as well relevant miRNAs that contribute to the development and maintenance of malignant cervical tumor cells. Finally, we recapitulate on miRNAs that may be used to distinguish between healthy individuals from patients with precancerous lesions or cervical tumors.

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Section: Hpv and Mirnasmentioning

confidence: 80%