MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts

Núñez‐Sánchez, María Ángeles; Dávalos, Alberto; González‐Sarrías, Antonio; Casas‐Agustench, Patricia; Visioli, Francesco; Monedero‐Saiz, Tamara; García‐Talavera, Noelia V.; Gómez‐Sánchez, María B.; Sánchez‐Álvarez, Carmen; García‐Albert, Ana M.; Rodríguez‐Gil, Francisco J.; Ruiz‐Marín, Miguel; Pastor-Quirante, Francisco; Martínez‐Díaz, Francisco; Tomás-Barberán, Francisco A.; Garcı́a-Conesa, María Teresa; Espı́n, Juan Carlos

doi:10.1002/mnfr.201500357

Cited by 64 publications

(42 citation statements)

References 49 publications

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“…Resveratrol, ellagic acid or green tea catechins [3,4,50] have been previously shown to modulate miRNA expression in certain tissues. We here provide additional evidence that HT, the foremost polyphenol of extra virgin olive oil and a unique component of the Mediterranean diet, also modulates the expression of miRNAs.…”

Section: Discussionmentioning

confidence: 99%

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Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

Tomé‐Carneiro

Crespo

Iglesias‐Gutiérrez

et al. 2016

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 99%

“…Within this context, the potential role of plant-derived phenolic molecules (e.g. polyphenols) in miRNAs modulation is being very actively investigated [3][4][5][6]. As of now, however, there is no clear published evidence of a definite direct effect of a polyphenol on a specific miRNA.…”

Section: Introductionmentioning

confidence: 98%

Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

Tomé‐Carneiro

Crespo

Iglesias‐Gutiérrez

et al. 2016

The Journal of Nutritional Biochemistry

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“…The only study that has tried to link the urolithins with possible effects in human tissues was recently reported by Núñez‐Sánchez et al. . Despite a moderate modulation of various CRC‐related microRNAs in the colon mucosa of CRC patients following pomegranate intake, no association between colon tissue urolithins and the observed microRNAs changes was observed.…”

Section: In Vitro and In Vivo Effects Of Urolithinsmentioning

confidence: 99%

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

Tomás-Barberán

González‐Sarrías

Garcı́a-Villalba

et al. 2016

Molecular Nutrition Food Res

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359

384

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Urolithins are dibenzo[b,d]pyran-6-one derivatives that are produced by the human gut microbiota from ellagitannins and ellagic acid (EA). These metabolites are much better absorbed than their precursors and have been suggested to be responsible for the health effects attributed to ellagitannins and EA that occur in food products as berries and nuts. In the present review, the role and potential of urolithins in human health are critically reviewed, and a perspective of the research approach needed to demonstrate these health effects is presented, based on the existing knowledge. The analytical methods available for urolithin analysis, their occurrence in different tissues and biological fluids, and their metabolism by human gut microbiota are considered. In addition, the interindividual variability observed for the production of urolithins (metabotypes) and its relationship with health status and dysbiosis are also reviewed. The potential mechanisms of action of urolithins are also critically discussed, paying attention to the concentration and the type of metabolites used in the in vitro and in vivo assays and the physiological significance of the results obtained. The gut microbiota metabolism of EA to urolithins and that of daidzein to equol, their individual variations, and the effects on health are also compared.

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“…Another randomized, double blind, controlled trial investigated the effects of pomegranate extract (900 mg daily) on 35 CRC patients. They reported that pomegranate extract markedly modulates various microRNAs responsible for the colorectal cancer in colon tissue of CRC patients (Nunez‐Sanchez et al, ). In another study, 57 patients with recently diagnosed colorectal cancer received two types of pomegranate extracts (PE) daily until the programmed surgery; PE‐1 contained 72 mg/g punicalagin, 2 mg/g punicalin and 294 mg/g EA derivatives, and PE‐2 contained 155 mg/g punicalagin, 5.4 mg/g punicalin and 28 mg/g EA derivatives.…”

Section: Resultsmentioning

confidence: 99%

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Rahimi

Ghadiri

Ramezani

et al. 2020

Phytotherapy Research

133

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Inflammation is commonly characterized as a defensive and protective reaction of the body to various exogenous or endogenous stimuli, which aims to maintain the body health. Punica granatum (pomegranate) and its constituent ellagic acid (EA) are recently more taken into accounts since their promising pharmacological effects. Therefore, we aimed to obtain a comprehensive review regarding antiinflammatory, anticancer, and antioxidant activities of both pomegranate and EA and their possible involved mechanisms. In the procedure, scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched in the English language, until the end of January 2019. Pomegranate belonging to the Punicaceae has been used for medical purposes from ancient and in different cultures. Several studies have also supported that EA is the major active compound of pomegranate and possesses antimutagenic, antiinflammatory, antifibrosis, anticancer, and antiaging properties. It has been suggested that pomegranate and EA possess promising immunomodulatory effects in preclinical models as well as human studies through regulation of the T‐cell function and suppressing humoral immunity. Hopefully, we wish that this review and information could be helpful for designing further experiments to investigate the potential protective effects of pomegranate and EA.

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MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts

Cited by 64 publications

References 49 publications

Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

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