MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in endometriosis — review of literature

Abstract

Endometriosis is a disease of the female genital organs, the causes of which are not fully understood. Recent studies have shown that non-coding RNAs (ncRNAs) like long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) can contribute to the pathogenesis of endometriosis. Profiling of miRNA and lncRNA expression is carried out using state-of-the-art molecular biology techniques (RT-PCR, sequencing, microarray analysis). The use of the latest technologies may make it possible to establish a genetic profile, which is a promising prospect for early diagnosis of endometriosis. In the future, genetic testing may become the gold diagnostic standard and eliminate invasive laparoscopy. In the case of endometriosis, it is important to extend the research to molecular aspects, which may facilitate the diagnosis of the disease or indicate new (based for example ncRNA) treatment methods. The paper presents the latest data on the importance of miRNA/lncRNA in endometriosis.

The Long Non-Coding RNA Gene AC027288.3 Plays a Role in Human Endometrial Stromal Fibroblast Decidualization

“…Previous findings have demonstrated the potential functions of some select lncR-NAs in the endometrium under pathological and physiological conditions. Abnormal expression of some lncRNAs in the endometrium or decidua is associated with fertility or gestational abnormalities such as endometriosis [12][13][14][15], recurrent implantation failure [16], and preeclampsia [17]. Some examples of the potential physiological role of lncRNA's in hESF decidualization so far include HAND2-AS1 [18], MALAT1 [15], ENSG00000230699 (LncSAMD11-1:1, [19], HK2P1 [20], TUNAR [21], LUCAT1 [22], and LINC00473 [23].…”