Microscale engineering of hollow microneedle tips: design, manufacturing, optimization and validation

Badnikar, Kedar; Jayadevi, Shreyas N.; Pahal, Suman; Vemula, Praveen Kumar; Nayak, M. M.; Subramanyam, Dinesh Narasimhaiah

doi:10.1007/s13346-021-01062-w

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Additionally, according to the presence or absence of cavities and types of cavity, MNs can be classified as hollow microneedles, 37,73–76 solid microneedles, 77–83 coated microneedles, 81,84–87 and porous microneedles. 1,40,88,89 Microneedles can collect ISF from the epidermis using different driving forces depending on the cavity type, such as capillary force, matrix swelling, and negative pressure.…”

Section: Classification Design and Fabrication Of Microneedlesmentioning

confidence: 99%

“…Thus, microneedle-based healthcare devices can be classified by purpose as (1) sampling of biomarkers in vivo followed by in vitro analysis 66-69 ; (2) in situ capture and detection of biomarkers in ISF 70-72 ; (3) delivery of loaded drugs or vaccines into ISF and the circulatory system in sequence 21,55 for applying required therapy for a specific disease, such as cancer. 54 Additionally, according to the presence or absence of cavities and types of cavity, MNs can be classified as hollow microneedles, 37, [73][74][75][76] solid microneedles, [77][78][79][80][81][82][83] coated --…”

Section: Classificationmentioning

confidence: 99%

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Advances in biomedical systems based on microneedles: design, fabrication, and application

Wang,

Xiao

et al. 2024

Biomater. Sci.

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Section: Classification Design and Fabrication Of Microneedlesmentioning

confidence: 99%

Section: Classificationmentioning

confidence: 99%

Advances in biomedical systems based on microneedles: design, fabrication, and application

Wang,

Xiao

et al. 2024

Biomater. Sci.

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“…Research indicates that the use of solid MN rollers to puncture the skin, followed by the application of EVs derived from human umbilical cord mesenchymal stem cells (HUC-MSCs), can effectively alleviate the symptoms of melasma patients, offering an enhanced experience for the patient [ 66 ]. Hollow MNs are similar in principle to the routine use of syringes and have clinical advantages in simple steps for doctors to follow [ 67 ]. As the name suggests, hollow MNs have holes in the tip and utilize a mechanism of “poke-and-flow” to deliver the drug to the skin tissue, which allows for high-dose administration compared to other types of MNs.…”

Section: Types and Materials Of Microneedlesmentioning

confidence: 99%

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Wang,

Cheng,

2024

Pharmaceutics

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Microneedles (MNs), renowned for their painless and minimally invasive qualities, exhibit significant potential for facilitating effective drug delivery, vaccination, and targeted sample extraction. Extracellular vesicles (EVs), serving as cargo for MNs, are naturally occurring nanovesicles secreted by cells and characterized by novel biomarkers, low immunogenicity, and cell-source-specific traits. MNs prove instrumental in extracting EVs from the sample fluid, thereby facilitating a promising diagnostic and prognostic tool. To harness the therapeutic potential of EVs in tissue repair, MNs with sustained delivery of EVs leverage micron-sized channels to enhance targeted site concentration, demonstrating efficacy in treating various diseases, such as Achillea tendinopathy, hair loss, spinal cord injury, and diabetic ulcers. EV-loaded MNs emerge as a promising platform for repair applications of skin, cardiac, tendon, hair, and spinal cord tissues. This review commences with an overview of MNs, subsequently delving into the role of EVs as cargo for MNs. The paper then synthesizes the latest advancements in the use of EV-loaded MNs for tissue regenerative repair, extending to research progress in extracting EVs from MNs for disease diagnosis and prognostic evaluations. It aims to offer valuable insights and forecast future research trajectories with the hope of inspiring innovative ideas among researchers in this field.

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“…Microneedles only pass through the stratum corneum and epidermis but do not touch the nerve fibres and blood vessels in the dermis [11]. The MNPs can provide better control over the drug release and may act as a depot or reservoir system, releasing the therapeutic drug for a longer period of time [12]. Therapeutically, this kind of dosage form reduces fluctuations in plasma drug concentrations, especially for drugs that have a short half-life.…”

Section: Introductionmentioning

confidence: 99%

Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance

Zulcaif

Zafar

Mahmood³

et al. 2022

Micromachines

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Microneedle patches (MNPs) are one of the emerging approaches for drug delivery involving minimal invasion and improved skin penetration of macro- and micro-entities. Herein, we report dissolvable microneedle patches (dMNPs) as a novel tool for better systemic delivery of Simvastatin in the management of hypocholesteremia. Thiolated chitosan (TC), polyvinyl pyrolidone (PVP) and polyvinyl alcohol (PVA) were employed in the development of dMNPs. Developed patches were characterized through SEM, FTIR, DSC, TGA, PXRD, dissolution testing, tensile strength, elongation (%), skin irritation studies, moisture content and pharmacokinetic evaluation. dMNP F26 exhibited excellent tensile strength (9.85 MPa), penetration potential (~700µm), moisture content (5.95%), elongation (35.54%) and Simvastatin release of 77.92%. Pharmacokinetic properties were also improved, i.e., Cmax 1.97 µg/mL, tmax 9 h, MRT 19.9 h and AUC 46.24 µg.h/mL as compared to Simvastatin solution displaying Cmax 2.55 µg/mL, tmax 3 h, MRT 5.91 h and AUC 14.20 µg.h/mL thus confirming higher and improved bioavailability. Kinetic modelling revealed zero order as the best fit model based on regression coefficient. Histopathological findings proved the biocompatibility of the developed dMNPs.

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Microscale engineering of hollow microneedle tips: design, manufacturing, optimization and validation

Cited by 5 publications

References 29 publications

Advances in biomedical systems based on microneedles: design, fabrication, and application

Advances in biomedical systems based on microneedles: design, fabrication, and application

Research Progress of Extracellular Vesicles-Loaded Microneedle Technology

Simvastatin Loaded Dissolvable Microneedle Patches with Improved Pharmacokinetic Performance

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