Microscopic Polyangiitis With Ocular Manifestations as the Initial Presenting Sign

Anterior Segment Manifestations of Microscopic Polyangiitis

“…Early diagnosis of vasculitic syndromes with proper management may prevent vision and life-threatening complications. In a retrospective review, Rothschild demonstrated that 8.9% (25/280) of patients with MPA developed ocular signs included episcleritis, scleritis, conjunctivitis, keratitis and uveitis [3]. We believe this is the first report of MPA presenting with PUK.…”

Ultra-Wide-Field Fluorescein Angiography in Microscopic Polyangiitis

“…Only 1 of the 85 patients in this study was found to have ocular involvement, although it was unclear how many of these patients were evaluated by an ophthalmologist. A 2007 publication reviewed all case reports of biopsy proven MPA and found only 8 cases of MPA with ocular manifestations, which ranged from central scotomas to conjunctivitis to optic disc edema to hypopyon [17]. …”

Microscopic Polyangiitis Manifesting as Lymphoma

“…6 Other reported cases of MPA with ocular involvement presented as peripheral nonulcerative keratitis and scleritis. 4,5,[7][8][9] Retinal cotton-wool spots, which represent nerve fiber layer infarcts and microvascular diseases, have been described in MPA. 9 Altaie et al also reported subacute optic neuropathy in patients with MPA.…”

“…3 A MEDLINE search from 1946 to the present identified 2 case reports of MPA with ocular manifestations as initial symptoms. 4,5 The first reported case of MPA involving the ocular area was a 23-year-old woman with renal failure and ulcerative skin. 6 Other reported cases of MPA with ocular involvement presented as peripheral nonulcerative keratitis and scleritis.…”