Fuel cells efficiently turn chemicals in fuel into electricity by chemical reaction and have been described as among the most recent advances in the upcoming cleaner energy sector. In recent times, fuel cells are being used in medicine, including experimental studies and current and potential goods, having numerous benefits over previous batteries, such as the convenience of recharging, eco-sustainable character, and high safety. This article highlights the up-to-date development of this energy system focusing on biofuel cells in implantable medical devices (IMDs) that use microbes, enzymes, and noble metals as catalysts. Furthermore, a diversity of fuel cell applications on the vitro medical kit (including alcohol tester, wound treatment instrument, blood glucose meter) was also described. The integration of fuel cells into implementable medical devices is at an initial phase of research, but this technology's possibility and potency is a reward. Obviously, after successfully integrating fuel cells into the patient's psyche, civilization will move throughout an innovative diagnostic transition.