2023
DOI: 10.1101/2023.12.06.570418
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Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function

Catharina R. Grubaugh,
Anuradha Dhingra,
Binu Prakash
et al.

Abstract: Lipid processing by the retinal pigment epithelium (RPE) is necessary to maintain retinal health and function. Dysregulation of retinal lipid homeostasis due to normal aging or to age-related disease triggers lipid accumulation within the RPE, on Bruch’s membrane (BrM), and in the subretinal space. In its role as a hub for lipid trafficking into and out of the neural retina, the RPE packages a significant amount of lipid into lipid droplets for storage and into apolipoprotein B (apoB)-containing lipoproteins (… Show more

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