Microsponges: A de novo Method for Colon Targeted Oral Drug Delivery

Hari, Kuralla; Prathyusha, S; Vasavi, Gokavarapu

doi:10.5530/ijpi.2020.3.44

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Table 1 covers the various microsponge formation procedures that have been used, as well as the merits and downsides of each methodology. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]…”

Section: Methods For Preparing Microspongesmentioning

confidence: 99%

A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective

Mandal,

Km Bhumika,

Kumar

et al. 2023

Ind. J. Pharm. Edu. Res

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Microsponges are porous microspheres ranging in size from 5 to 300 micrometers used in a polymeric delivery system. They have been studied for biomedical applications, including targeted medicine delivery, transdermal drug delivery, anticancer drug delivery, and bone substitutes. This research aims to conduct a detailed examination of existing trends and future prospects for a microsponge-based medicine delivery system. The current study investigates the Microsponge Delivery System's design, operation, and possible therapeutic uses (MDS). The therapeutic potential of microsponge-based formulations, as well as patent data, were thoroughly investigated. The authors discuss several efficient methods for producing microsponges, including liquid-liquid suspension polymerization, quasi-emulsion solvent diffusion, water-in-oil-in-water (w/o/w) emulsion solvent diffusion, oil-in-oil emulsion solvent diffusion, the lyophilization method, the porogen addition method, the vibrating orifice aerosol generator method, the electrohydrodynamic atomization method, and the ultrasound-assisted microsponge. Microsponge may reduce undesired side effects and increase drug stability by boosting drug release. Hydrophilic and hydrophobic drugs can be loaded into a microsponge and transported to a specific target. When compared to traditional distribution methods, microsponge delivery technology offers numerous advantages. Microsponges, which are spherical, sponge-like nanoparticles with porous surfaces, can help increase drug stability. They efficiently alter drug release while also reducing adverse effects.

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Section: Methods For Preparing Microspongesmentioning

confidence: 99%

A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective

Mandal,

Km Bhumika,

Kumar

et al. 2023

Ind. J. Pharm. Edu. Res

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“… It is used as skin de-pigmenting agent (hydroquinone) 13 . Flucinolone acetonide, an anti-inflammatory gel, is prepared using eudragit micro sponge which helps to reduce skin inflammation and to get relief from skin irritation 14 .…”

Section: Use Of Microspongesmentioning

confidence: 99%

Untitled

2022

IJPSR

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Micro sponges are patented polymeric drug delivery systems consisting of porous microspheres. The physical appearance of microsponges is tiny spherical sponge-like with the surface with large spores. Micro sponges are typically used and nowadays used as the oral dosage form. The inert and indestructible tiny spherical particles do not pass through the skin. But, it collects in the tiny nooks and crannies of skin. Thus slowly release the drug for a prolonged period. It prevents the excess accumulation of drugs within the epidermis and dermis. They have a modified drug release pattern with lesser side effects. Micro sponges are biologically safe and provide a selective advantage of programmable drug release. Micro sponges Drug Delivery System provides entrapment of ingredients because of its porous nature and is believed to contribute lesser side effects, improve drug stability, increase elegance, and enhance formulation flexibility. One of the best features of microsponges is their self-sterilizing property. Several studies have confirmed that Micro sponges are non-mutagenic, non-allergic, non-irritant, and non-toxic. This review focused on preparation, characterization, release mechanism, and other Micro sponges Drug Delivery System parameters.

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