Microsponges enriched gel for enhanced topical delivery of 5-fluorouracil

Jain, Subheet Kumar; Kaur, Manreet; P, Kalyani; Mehra, Anshula; Kaur, Navjot; Panchal, Neha

doi:10.1080/02652048.2019.1667447

Cited by 30 publications

(14 citation statements)

References 27 publications

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“…Besides topical drug delivery, a microsponge delivery system was investigated for colon targeted drug delivery systems earlier, dispensing in capsule [1] and tablet [2]. In previous years, researchers prepared and characterised microsponges entrapping various types of drugs, such as 5 -FU [3,4]; antifungal drugs-ketoconazole, miconazole, fluconazole, terbinafin HCl [5][6][7], antihypertensive drugs-nebivolol, valsartan [8,9], an anti-inflammatory drugketoprofen [10], timolol, used for glaucoma [11], antiviral drugs-valcyclovir, acyclovir [12,13], anthelmintic drug-albendazole [14]. Commercially microsponge delivery system is gaining importance as dermal and cosmetic products.…”

Section: Introductionmentioning

confidence: 99%

“…The use of Eudragit polymer had been reported in the preparation of microparticles by several investigators [3,7,8,14,[17][18][19][20][21]; use of ethylcellulose polymer was found in several earlier works [5,6,12,16,[22][23][24][25][26]; eudragit RSPO by P.M. Barde et al [27], as a single polymer use. A combination of polymers (ethyl cellulose +HPMC) was used by Yasser Shahzada et al [10] and Jain S.K et al (ethyl cellulose +eudragit RL 30D) [4]. The coupling of different polymers offers better control of drug release behaviour.…”

Section: Introductionmentioning

confidence: 99%

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WITHDRAWN: Optimization and Scale-up Methodology in Preparing Microsponge Loaded with 5-Fluorouracil (5-FU).

Halder

Poddar²,

Khanam

2021

Preprint

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The present investigation aims at developing models by response surface methodology (FCCCD) followed by the scale-up method in preparing control release microsponge particles loaded with 5- fluorouracil, a drug used to treat actinic keratosis and colon cancer, and producing a new Dermal Delivery System. The polymer-based (ethyl cellulose and eudragit RS 100) microsponge particles were prepared by the w/o/w double emulsification method. The optimized product was formed with the combination of independent variables levels: polymer (600 mg), stirring speed (1198 rpm) and surfactant (2% w/v), yielding responses as yield (~63.6257%), the average size of particles (~151.563 µm), entrapment efficiency (~75.319 %) and drug release in 8hr (~75.75%), with desirability value of 0.737. The products showed similar responses as obtained in scale-up work. FT-IR, DSC and SEM studies confirmed the drug's compatibility with polymers and porous morphology. Finally, gel embedded optimised product showed shear-thinning rheological property, ideal for drug release from the thixotropic gel.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Optimization and Scale-up Methodology in Preparing Microsponge Loaded with 5-Fluorouracil (5-FU).

Halder

Poddar²,

Khanam

2021

Preprint

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“…5-FU is a pyrimidine analogue, an anti-neoplastic antimetabolite blocks the enzyme liable for the synthesis of thymidine (DNA), alters the DNA replication and subsequent induction of apoptosis [69,72]. 5-FU topical cream (5%) is one of the first-line treatment choices.However, its local tolerance and skin permeation are poor and cause inflammation, itching and irritation [74].…”

Section: Microsponges For Skin Cancermentioning

confidence: 99%

Therapeutic Application of Microsponges-based Drug Delivery Systems

Rahman

Almalki

Panda³

et al. 2022

CPD

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Microsponges delivery system (MDS) is highly porous, cross-linked based polymeric systems, that activates in the presence of temperature, rubbing and pH. MDS offers wide range of advantage, like controlled drug release, site-specific action, stable over a broad range of pH, poor irritation, cost effective, improved patient compliance. They can be transformed into various dosage forms like creams, gels, and lotions. MDS based system are suitable for treatment of topical disorders like acne, psoriasis, dandruff, eczema, scleroderma, hair loss, skin cancer, and other dreadful diseases. MDS application for drug delivery is not limited to topical drug delivery but also explored for oral, parenteral and pulmonary drug delivery. Microsponges were studied for colon targeting of drugs and genes. Additionally, MDS has wide application for sunscreen, cosmetics, and over the counter (OTC) products. Furthermore, MDS does not actuate any irritation, genotoxicity, immunogenicity or cytotoxicity. Therefore, this review extensively highlights about microsponges, their advantages, key factors affecting the micro-sponges’ characteristics, the therapeutic application of microsponges in topical disorders, cancer, as cosmetics, recent advances in MDS and addresses the associated challenges.

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“…Hence, the developed microsponges based formulation seems to be a viable alternative with enhanced topical delivery of 5-FU as compared to the commercial formulation (Jain et al, 2019).…”

Section: Anti-cancermentioning

confidence: 99%

Drug Delivery from Microsponges: A Review Article

Gad

Elosaily

Mahrous³

et al. 2021

Records of Pharmaceutical and Biomedical Sciences

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Microsponges are micro-porous particles, used mainly for topical and recently for oral administration. Microsponges have many advantages which make it a versatile drug delivery system. Microsponges can suspended or entrap a wide variety of substances and then be incorporated into a formulated product such as a gel, cream, liquid, or powder. Moreover, they may enhance stability, reduce side effects and modify drug release related to its porous structure which allows the active ingredient to sustain over time. The aim of this article is to provide details about microsponges including the method of preparation, characterization, mechanism of drug release from microsponges, different formulation and process factors, and a few applications about microsponges which are either proven or under research.

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Microsponges enriched gel for enhanced topical delivery of 5-fluorouracil

Cited by 30 publications

References 27 publications

WITHDRAWN: Optimization and Scale-up Methodology in Preparing Microsponge Loaded with 5-Fluorouracil (5-FU).

WITHDRAWN: Optimization and Scale-up Methodology in Preparing Microsponge Loaded with 5-Fluorouracil (5-FU).

Therapeutic Application of Microsponges-based Drug Delivery Systems

Drug Delivery from Microsponges: A Review Article

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