In this research, the effect of fillers wires on weldability, welding strength and structural changes of dissimilar welds of Inconel 718 and AISI 316L are studied. Pulse arc mode in TIG welding with multiple passes were used to join V-groove configuration with 1.6 mm filler diameter. Constant welding parameters were used for both the weldments to study the effect of alloying elements of filler wires. Tensile properties were evaluated by conducting tensile test on universal testing machine as per ASTM E/8 standards. To reveal the structural changes at various zones of weldment, optical microscope was utilized. The dissimilar metals were joined successfully using two-filler wires without any internal defects. The highest tensile strength of 553 MPa was observed in Hastelloy filler weldment when compared with ERNiCrMo-4 filler weldment (530 MPa). Also, the better yield strength properties were observed in Hastelloy filler weldment. Well defined with clear grain boundaries were observed in both the filler weldments. Due to the pulsed arc mode, segregation of alloying elements was reduced.