Microstructural, mechanical properties and strengthening mechanism of DLP produced β-tricalcium phosphate scaffolds by incorporation of MgO/ZnO/58S bioglass

Zhang, Hang; Xiong, Yinze; Dong, Lanlan; Shen, Yifan; Hu, Hongxing; Gao, Hong; Zhao, Shichang; Li, Xiang

doi:10.1016/j.ceramint.2021.05.317

Cited by 14 publications

(9 citation statements)

References 38 publications

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“…Another interesting inference is the regulation of osteogenic gene expression by the ionic release. 70 The 50:50 ratio of the BG/β-TCP composite scaffold improved the MSCs proliferation better than the 100%β-TCP scaffold. 71 Salamanca et al also indicated an increase in osteoblastic activity with the incorporation of 5% MgO into the β-TCP scaffold.…”

Section: Biocompatibility and Bioresorbability Studies On Additive Ma...mentioning

confidence: 98%

“…Another work reported that the addition of 0.5% ZnO and 1% MgO to the β-TCP scaffold, increased the compressive strength to 24.09 MPa when fabricating using the DLP technique. By further adding 2% of BG to the 0.5ZnO/1MgO/β-TCP composition, the compression strength and fracture toughness of the scaffold was improved to 33.79 and 3.10 MPa·m 1/2 , respectively …”

Section: Physical and Mechanical Characteristics Of Additive Manufact...mentioning

confidence: 99%

“…The release of Mg 2+ , Zn 2+ , and Si 4+ ions increased cell adhesion, proliferation, and ALP activity compared to undoped β-TCP scaffolds. Another interesting inference is the regulation of osteogenic gene expression by the ionic release . The 50:50 ratio of the BG/β-TCP composite scaffold improved the MSCs proliferation better than the 100%β-TCP scaffold .…”

Section: Biocompatibility and Bioresorbability Studies On Additive Ma...mentioning

confidence: 99%

“…By further adding 2% of BG to the 0.5ZnO/ 1MgO/β-TCP composition, the compression strength and fracture toughness of the scaffold was improved to 33.79 and 3.10 MPa•m 1/2 , respectively. 70 Due to the intrinsic fragility of β-TCP, it is often combined with other functional bioceramic materials to have better mechanical characteristics. The 45S5/β-TCP composite scaffold in the 50:50 ratio is fabricated using the robocasting technique recording the compressive strength of 17.39 MPa for 40% porosity.…”

Section: Tricalcium Phosphatesmentioning

confidence: 99%

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Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

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This review focuses on the advancements in additive manufacturing techniques that are utilized for fabricating bioceramic scaffolds and their characterizations leading to bone tissue regeneration. Bioscaffolds are made by mimicking the human bone structure, material composition, and properties. Calcium phosphate apatite materials are the most commonly used scaffold materials as they closely resemble live bone in their inorganic composition. The functionally graded scaffolds are fabricated by utilizing the right choice of the 3D printing method and material combinations to achieve the requirement of the bioscaffold. To tailor the physical, mechanical, and biological properties of the scaffold, certain materials are reinforced, doped, or coated to incorporate the functionality. The biomechanical loading conditions that involve flexion, torsion, and tension exerted on the implanted scaffold are discussed. The finite element analysis (FEA) technique is used to investigate the mechanical property of the scaffold before fabrication. This helps in reducing the actual number of samples used for testing. The FEA simulated results and the experimental result are compared. This review also highlights some of the challenges associated while processing the scaffold such as shrinkage, mechanical instability, cytotoxicity, and printability. In the end, the new materials that are evolved for tissue engineering applications are compiled and discussed.

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Section: Biocompatibility and Bioresorbability Studies On Additive Ma...mentioning

confidence: 98%

Section: Physical and Mechanical Characteristics Of Additive Manufact...mentioning

confidence: 99%

Section: Biocompatibility and Bioresorbability Studies On Additive Ma...mentioning

confidence: 99%

Section: Tricalcium Phosphatesmentioning

confidence: 99%

See 2 more Smart Citations

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

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“…The raw materials are costly because they depend on high-priced photosensitive materials [15]. Efforts have been made to reduce feedstock [200][201][202][203] Bone repair/tissue engineering Hydroxyapatite [204][205][206][207][208][209][210][211][212][213][214][215][216], TCP [217][218][219][220][221][222][223][224][225][226][227][228], Al 2 O 3 [229], biosilicate [230], baghdadite [231][232][233], wollastonite-diopside [234], Mgsubstituted wollastonite [235,236], hydroxyapatite+TCP [237][238][239][240][241][242], hydroxyapatite+akermanite [243], calcium phosphate+bioglass [54,…”

Section: Vat Photopolymerizationmentioning

confidence: 99%

A review on the ceramic additive manufacturing technologies and availability of equipment and materials

2022

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Ceramic additive manufacturing allows the fabrication of small series of complex parts without the high costs of molds usually associated with traditional ceramic processing. Although research into ceramic 3D printing by all technologies started back in the 90s, its industrial application is still quite restricted when compared to polymers and metals, which is related to the limited availability and costs of equipment and materials for such applications. This review examined the advantages and limitations of each process (binder jetting, direct ink writing, directed energy deposition, fused deposition, material jetting, selective laser sintering, selective laser melting, and vat photopolymerization), discussing their particularities. It also summarized the commercially available 3D printers and raw materials for ceramic processing, pointing out to trends and challenges of each technology.

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Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

118

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It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, from short life function replacement to permanent regeneration repair. At present, bone transplantation has become the second largest transplantation surgery after blood transfusion, and artificial bone transplantation generates great hope for the repair and treatment of bone defect. In order to repair bone defect, artificial bone must have good biological properties and sufficient mechanical properties, and it should also have the shape matching to bone defect site and the connected porous structure. For structures and properties requirements of artificial bone, in this review three major challenges faced by artificial bone transplantation are systemtically analyzed and current methods and strategies to address these issues are discussed: 1) the need for developing a type of bone scaffold material with both biological and mechanical properties, 2) the need for realizing the controllable fabrication of individual shape and multistage pore structure of bone scaffold, 3) the need for realizing the transformation from man‐made structure to biological structure. Besides, it summarizes the advantages and disadvantages of these methods and discusses the potential future directions of structural and functional adaptive artificial bone for bone defect regeneration.

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Microstructural, mechanical properties and strengthening mechanism of DLP produced β-tricalcium phosphate scaffolds by incorporation of MgO/ZnO/58S bioglass

Cited by 14 publications

References 38 publications

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

A review on the ceramic additive manufacturing technologies and availability of equipment and materials

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

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