Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study

Bukkieva, T. A.; Поспелова, М. Л.; Efimtsev, A. Yu.; Фионик, О. В.; Алексеева, Т. М.; Samochernykh, Konstantin; Горбунова, Е. А.; Krasnikova, Varvara; Makhanova, Albina; Nikolaeva, A. E.; Tonyan, S. N.; Lepekhina, A.S.; Levchuk, Anatoliy; Труфанов, Г. Е.; Akshulakov, Serik; Shevtsov, Maxim

doi:10.3390/pathophysiology29040046

Cited by 7 publications

(1 citation statement)

References 56 publications

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“…Additionally, to complete the list of reported genes, this study utilized bioinformatical approaches and databases to introduce new related genes. By combining the bioinformatics results as the suggested in silico findings (level 1) and the literature reports as the experimentally evidenced (level 2), a new potential gene list is introduced (level 3) ( Table 1 ) [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

Personalized Medicine in Cancer Pain Management

Raad

López

Sharafshah

et al. 2023

JPM

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Background: Previous studies have documented pain as an important concern for quality of life (QoL) and one of the most challenging manifestations for cancer patients. Thus, cancer pain management (CPM) plays a key role in treating pain related to cancer. The aim of this systematic review was to investigate CPM, with an emphasis on personalized medicine, and introduce new pharmacogenomics-based procedures for detecting and treating cancer pain patients. Methods: This study systematically reviewed PubMed from 1990 to 2023 using keywords such as cancer, pain, and personalized medicine. A total of 597 publications were found, and after multiple filtering processes, 75 papers were included. In silico analyses were performed using the GeneCards, STRING-MODEL, miRTargetLink2, and PharmGKB databases. Results: The results reveal that recent reports have mainly focused on personalized medicine strategies for CPM, and pharmacogenomics-based data are rapidly being introduced. The literature review of the 75 highly relevant publications, combined with the bioinformatics results, identified a list of 57 evidence-based genes as the primary gene list for further personalized medicine approaches. The most frequently mentioned genes were CYP2D6, COMT, and OPRM1. Moreover, among the 127 variants identified through both the literature review and data mining in the PharmGKB database, 21 variants remain as potential candidates for whole-exome sequencing (WES) analysis. Interestingly, hsa-miR-34a-5p and hsa-miR-146a-5p were suggested as putative circulating biomarkers for cancer pain prognosis and diagnosis. Conclusions: In conclusion, this study highlights personalized medicine as the most promising strategy in CPM, utilizing pharmacogenomics-based approaches to alleviate cancer pain.

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Section: Resultsmentioning

confidence: 99%

Personalized Medicine in Cancer Pain Management

Raad

López

Sharafshah

et al. 2023

JPM

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Harnessing the frontal aslant tract’s structure to assess its involvement in cognitive functions: new insights from 7-T diffusion imaging

Serrano-Sponton,

Lange,

Dauth

et al. 2024

Sci Rep

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The first therapeutical goal followed by neurooncological surgeons dealing with prefrontal gliomas is attempting supramarginal tumor resection preserving relevant neurological function. Therefore, advanced knowledge of the frontal aslant tract (FAT) functional neuroanatomy in high-order cognitive domains beyond language and speech processing would help refine neurosurgeries, predicting possible relevant cognitive adverse events and maximizing the surgical efficacy. To this aim we performed the recently developed correlational tractography analyses to evaluate the possible relationship between FAT’s microstructural properties and cognitive functions in 27 healthy subjects having ultra-high-field (7-Tesla) diffusion MRI. We independently assessed FAT segments innervating the dorsolateral prefrontal cortices (dlPFC-FAT) and the supplementary motor area (SMA-FAT). FAT microstructural robustness, measured by the tract’s quantitative anisotropy (QA), was associated with a better performance in episodic memory, visuospatial orientation, cognitive processing speed and fluid intelligence but not sustained selective attention tests. Overall, the percentual tract volume showing an association between QA-index and improved cognitive scores (pQACV) was higher in the SMA-FAT compared to the dlPFC-FAT segment. This effect was right-lateralized for verbal episodic memory and fluid intelligence and bilateralized for visuospatial orientation and cognitive processing speed. Our results provide novel evidence for a functional specialization of the FAT beyond the known in language and speech processing, particularly its involvement in several higher-order cognitive domains. In light of these findings, further research should be encouraged to focus on neurocognitive deficits and their impact on patient outcomes after FAT damage, especially in the context of glioma surgery.

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Connectivity in the Dorsal Visual Stream is Enhanced in Action Video Game Players

Cahill,

Jordan,

Dhamala

2024

Preprint

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Action video games foster competitive environments that demand rapid spatial navigation and decision-making. Action video gamers often exhibit faster response times and slightly improved accuracy in vision-based sensorimotor tasks. However, the underlying functional and structural changes in the two visual streams of the brain that may be contributing to these cognitive improvements have been unclear. Using functional and diffusion MRI data, this study investigated the differences in connectivity between gamers who play action video games and nongamers in the dorsal and ventral visual streams. We found that action video gamers have enhanced functional and structural connectivity, especially in the dorsal visual stream. Specifically, there is heightened functional connectivity both undirected and directed between the left Superior Occipital Gyrus and the left Superior Parietal Lobule during a moving-dots discrimination decision-making task. This increased connectivity correlates with response time in gamers. The structural connectivity, as quantified by diffusion fractional anisotropy and quantitative anisotropy measures of the axonal fiber pathways between the same regions was also enhanced for gamers compared to nongamers. These findings provide valuable insights into how action video gaming can induce targeted neuroplastic changes, enhancing structural and functional connectivity between specific brain regions in the visual processing pathways. These connectivity changes in the dorsal visual stream underpin the superior performance of action video gamers compared to non-gamers in tasks requiring rapid and accurate vision-based decision-making.

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Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study

Cited by 7 publications

References 56 publications

Personalized Medicine in Cancer Pain Management

Personalized Medicine in Cancer Pain Management

Harnessing the frontal aslant tract’s structure to assess its involvement in cognitive functions: new insights from 7-T diffusion imaging

Connectivity in the Dorsal Visual Stream is Enhanced in Action Video Game Players

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