Microstructural white matter alterations in psychotic disorder: A family-based diffusion tensor imaging study

Domen, Patrick; Michielse, Stijn; Gronenschild, E. H. B. M.; Habets, Petra; Roebroeck, Alard; Schruers, Koen; Os, Jim van

doi:10.1016/j.schres.2013.03.002

Cited by 19 publications

(30 citation statements)

References 78 publications

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“…At baseline, there was no significant difference in whole brain mean FA between siblings and controls, whereas such a difference was apparent between siblings and patients. 24 At follow-up, siblings showed a significant lower whole brain mean FA with respect to the controls and the significant difference with patients was no longer apparent. The difference at follow-up was confirmed by a significant FA decrease over time in siblings compared to controls, which was not observed in patients.…”

Section: Findings In Siblingsmentioning

confidence: 87%

“…Given the absence of (1) differences in alcohol consumption across groups, (2) other drug use in the controls and siblings, and (3) effects of other drug use on microstructural WM in the baseline study, 24 sensitivity analyses for these substances were not considered additional informative.…”

Section: Methodological Considerationsmentioning

confidence: 99%

“…in the Netherlands. 25 The magnetic resonance imaging (MRI) add-on study was conducted in Maastricht, the Netherlands (see Domen and colleagues 24 or the Supplemental Method section for full information on in-and exclusion criteria of the participants and diagnostic assessments). For the baseline MRI study, 300 participants were included of which 258 provided a valid DTI scan: 85 patients with a psychotic disorder, 93 siblings without a psychotic disorder, and 80 healthy controls.…”

Section: Participantsmentioning

confidence: 99%

“…23 In our recent cross-sectional diffusion analyses of patients with a psychotic disorder, siblings and controls (n = 258), patient-specific microstructural WM alterations were found in the corpus callosum and other WM tracts. 24 This sample was re-scanned approximately 3 years later to examine whether the evolution of FA over time varies as a function of familial risk for psychotic disorder.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Domen¹,

Peeters²,

Michielse³

et al. 2016

Schizophrenia Bulletin

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Section: Findings In Siblingsmentioning

confidence: 87%

Section: Methodological Considerationsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Domen¹,

Peeters²,

Michielse³

et al. 2016

Schizophrenia Bulletin

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“…26 Disruptions in WM organization (reflected in reductions in FA) can result from various mechanisms, including demyelination as well as axonal loss and lacks pathologic specificity. However, the other DTI-derived measures, such as RD and AD, are thought to reflect myelin and axonal integrity, respectively.…”

Section: Discussionmentioning

confidence: 99%

DTI Correlates of Cognition in Conventional MRI of Normal-Appearing Brain in Patients with Clinical Features of Subacute Combined Degeneration and Biochemically Proven Vitamin B12 Deficiency

Gupta

Garg

et al. 2013

American Journal of Neuroradiology

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Structural connectivity associated with familial risk for mental illness: A meta‐analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders

Zhang

Hochwalt

et al. 2022

Human Brain Mapping

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Schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) are heritable conditions with overlapping genetic liability. Transdiagnostic and disorderspecific brain changes associated with familial risk for developing these disorders remain poorly understood. We carried out a meta-analysis of diffusion tensor imaging (DTI) studies to investigate white matter microstructure abnormalities in relatives that might correspond to shared and discrete biomarkers of familial risk for psychotic or mood disorders. A systematic search of PubMed and Embase was performed to identify DTI studies in relatives of SCZ, BD, and MDD patients. Seed-based d Mapping software was used to investigate global differences in fractional anisotropy (FA) between overall and disorder-specific relatives and healthy controls (HC). Our search identified 25 studies that met full inclusion criteria. A total of 1,144 relatives and 1,238 HC were included in the meta-analysis. The overall relatives exhibited decreased FA in the genu and splenium of corpus callosum (CC) compared with HC. This finding was found highly replicable in jack-knife analysis and subgroup analyses. In disorder-specific analysis, compared to HC, relatives of SCZ patients exhibited the same changes while those of BD showed reduced FA in the left inferior longitudinal fasciculus (ILF). The present study showed decreased FA in the genu and splenium of CC in relatives of SCZ, BD, and MDD patients, which might represent a shared familial vulnerability marker of severe mental illness. The white matter abnormalities in the left ILF might represent a specific familial risk for bipolar disorder.

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Microstructural white matter alterations in psychotic disorder: A family-based diffusion tensor imaging study

Cited by 19 publications

References 78 publications

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

DTI Correlates of Cognition in Conventional MRI of Normal-Appearing Brain in Patients with Clinical Features of Subacute Combined Degeneration and Biochemically Proven Vitamin B12 Deficiency

Structural connectivity associated with familial risk for mental illness: A meta‐analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders

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