Microsynthesis and electron ionization mass spectral studies of O(S)‐alkyl N,N‐dimethyl alkylphosphono(thiolo)thionoamidates for Chemical Weapons Convention verification

Abstract

Mass spectra of the synthesized compounds were investigated with the aim to enrich the Organization for the Prohibition of Chemical Weapons (OPCW) Central Analytical Database (OCAD) which may be used for detection and identification of CWC-related chemicals during on-site inspection and/or off-site analysis such as OPCW proficiency tests.

Mass spectral characterization of the CWC‐related isomeric dialkyl alkylphosphonothiolates/alkylphosphonothionates under gas chromatography/mass spectrometry conditions

“…reported the thiono‐thiolo rearrangement in O ‐alkyl‐ N,N ‐dimethyl alkylphosphonothionoamidates, based on observation of unexpected loss of the • SR radical, which was equal to or more abundant than the expected • OR radical loss. They further supported the occurrence of the rearrangement with theoretical calculations . Barr et al .…”

“…They further supported the occurrence of the rearrangement with theoretical calculations. [41] Barr et al studied a few dimethyl methylphosphonothionates (isotopically labelled) under ESI conditions and found that their protonated molecules undergo thiono-thiolo rearrangement. [32] Although many examples of thiono-thiolo rearrangement have been reported, it has not been explored in the case of dialkyl alkylphosphonothionates.…”

Fragmentation pathways and structural characterization of organophosphorus compounds related to the Chemical Weapons Convention by electron ionization and electrospray ionization tandem mass spectrometry

“…Therefore, there has been a worldwide concern to eliminate the presence of chemical weapons. In the investigation of chemical warfare terrorism and the pursuit of disarmament activities, the detection of CWAs is an important task to protect both civilians and security personnel . To ensure that the Chemical Weapons Convention (CWC) treaty is respected, the detection of trace levels and the identification of CWC‐related compounds are required in a variety of environmental samples .…”

Gas Chromatography-Mass Spectrometric Studies of O-Alkyl O-2-(N,N-Dialkylamino) Ethyl Alkylphosphonites(Phosphonates) for Chemical Weapons Convention Verification

“…[1][2][3] This convention, which prohibits development, production, stockpiling and use of chemical weapons, was available for signature on January 13, 1993 and came into force on April 29, 1997. For CWC implementation, toxic chemicals, precursors and most related chemicals are listed in three distinct CWC schedules contained in the annex on chemicals.…”