Microtermolides A and B from Termite-Associated <i>Streptomyces</i> sp. and Structural Revision of Vinylamycin

Carr, Gavin; Poulsen, Michael; Klassen, Jonathan L.; Hou, Yunfei; Wyche, Thomas P.; Bugni, Tim S.; Currie, Cameron R.; Clardy, Jon

doi:10.1021/ol301043p

Cited by 97 publications

(100 citation statements)

References 18 publications

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“…However, the study of microbiota in invertebrates is recent. The symbiotic relationships between bacteria, fungi and insects have been well described by Currie and Clardy group (Carr et al, 2012;Poulsen et al, 2011, Poulsen, 2010 utilizing colonies of ants, termites, beetles and wasps. Several novel natural products and some already known ones have been identified in symbiotic microorganisms of social insects, demonstrating how promising this research area is, since insects constitute a large class of the Arthropoda Phylum, being the largest group of animals in species.…”

Section: Natural Productsmentioning

confidence: 99%

“…There are several studies demonstrating these types of associations between animals, plants and microorganisms. However, little is known about the mechanisms of interactions (Ramadhar et al, 2014;Carr et al, 2012;Gasparini et al, 2008;Nogueira-Neto, 1997). Symbiotic relationships in insects are usually associated with improvements in the nutritional factor of their food, with increased defense against pathogens and protection of the litter.…”

Section: Symbiosismentioning

confidence: 99%

“…Fungi are also associated with insects and have been well studied with ecto and endosymbiosis of fungi with garden ants, termites, wasps and beetles (Ramadhar et al, 2014;Carr et al, 2012). In the same way as this cooperation with which these types of societies normally are common in nature, often infectious diseases can wipe out whole nests much more quickly than if they do not live in the symbiotic community (Cremer et al, 2007).…”

Section: Insect Association With Microorganismsmentioning

confidence: 99%

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Untitled

2017

IBSPR

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Chemical ecology studies are needed to better understand the relationships between species and how the production of secondary metabolites influences these associations. The symbiotic relationship between insects, fungi and bacteria has been investigated and new findings in the area have shown how these relationships have evolved and which substances are involved in this co-operation. It is known that ants, termites, and bees have a symbiotic relationship with fungi and bacteria, which produce products of potential pharmacological or agricultural importance. The search for new natural products in this area is not only to find potential antibiotics, but to evaluate if these substances have other biological effects/activities, such as anticancer, antileishmania and antichagasic. Often through structural elucidation, one can recognize potential hits or drug prototypes. Moreover, most of the antifungal and antibacterial agents have originated from natural products or are analogues thereof. The need for new strategies to obtain antibiotics is urgent, since resistance is one of the main factors of mortality in patients treated with this type of medication. Analyzing this symbiotic relationship among living beings, it seems to be an innovative strategy to seek new medicines.

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Section: Natural Productsmentioning

confidence: 99%

Section: Symbiosismentioning

confidence: 99%

Section: Insect Association With Microorganismsmentioning

confidence: 99%

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Untitled

2017

IBSPR

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“…Microtermolides A and B were isolated from a Streptomyces sp. strain associated with fungusgrowing termites (Carr et al, 2012). Microtermolide A contains a FA acid [51].…”

Section: Branched Saturated and Unsaturated Fatty Acidsmentioning

confidence: 99%

Paradigm Shifts in Fungal Secondary Metabolite Research: Unusual Fatty Acids Incorporated into Fungal Peptides

Dembitsky¹

2017

Int. J. Curr. Res. Biosci. Plant Biol.

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A b s t r a c t A r t i c l e I n f oThis review is a comprehensive survey of unique, unusual, and rare fatty acids incorporated into natural marine and terrestrial peptides obtained from fungi, fungal endophytes, lichenized ascomycetes, basidiomycetes, and actinomycetes. Lots of fungal peptides display important biological activities of interest, which includes antitumor, antibacterial, antimicrobial, antifungal, phototoxic, HIV inhibitory, immunosuppressive properties, and other pharmacological activities. There is no doubt that they are of great importance, especially in medicinal chemistry and/or pharmaceutical application. This review presents structures of more than 150 fatty acids, incorporated into marine and terrestrial fungal lipopeptides.

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“…residing in the gut of the termite Odontotermes formosanus (Bi et al 2011), and polyketide synthase-nonribosomal peptide synthetase hybrid natural products, macrotermolides A (16) have been discovered from a termite-associated Streptomyces sp. (Carr et al 2012) Furthermore, continuous research on the secondary metabolites of termite-associated actinomycetes from Macrotermes natalensis colonies led to the isolation of a highly modified geldanamycin compound, natalamycin A (17) (Kim et al 2014), and the antifungal compounds, tyroscherin and N-methyltyroscherin (18), were identified in a Pseudallescheria boydii fungal strain isolated from the termite Nasutitermes sp. in France (Nirma et al 2013).…”

Section: Chemical Biology Of Gut Bacteria and Their Secondary Metabolmentioning

confidence: 99%

Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy

Choi

2015

Arch. Pharm. Res.

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Conventional approaches to natural product drug discovery rely mainly on random searches for bioactive compounds using bioassays. These traditional approaches do not incorporate a chemical biology perspective. Searching for bioactive molecules using a chemical and biological rationale constitutes a powerful search paradigm. Here, the authors review recent examples of the discovery of bioactive natural products based on chemical and biological interactions between hosts and symbionts, and propose this method provides a more effective means of exploring natural chemical diversity and eventually of discovering new drugs.

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Microtermolides A and B from Termite-Associated Streptomyces sp. and Structural Revision of Vinylamycin

Cited by 97 publications

References 18 publications

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Paradigm Shifts in Fungal Secondary Metabolite Research: Unusual Fatty Acids Incorporated into Fungal Peptides

Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy

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