Microtubule Plus-End Dynamics Visualization in Huntington's Disease Model based on Human Primary Skin Fibroblasts

Taran, Aleksandra; Belikova, L. N.; Lavrushkina, Svetlana; Bogomazova, Alexandra N.; Lagarkova, Maria A.; Alieva, Irina B.

doi:10.3791/62963

Cited by 1 publication

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“…HTT also interacts with both N- and C-terminal domains with dynamite 1 [ 112 , 121 , 122 ]. Our own experimental data give reason to believe that a significant part of the HTT-involved cellular processes is mediated by microtubules and other cell cytoskeleton structures [ 123 , 124 ]. HTT is involved in autophagy (reviewed in [ 125 , 126 ]).…”

Section: Huntingtin–protein Interactions As the Basis Of Intracellula...mentioning

confidence: 99%

Huntingtin and Other Neurodegeneration-Associated Proteins in the Development of Intracellular Pathologies: Potential Target Search for Therapeutic Intervention

(Taran)

Shakhov

Kotlobay

et al. 2022

IJMS

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Neurodegenerative diseases are currently incurable. Numerous experimental data accumulated over the past fifty years have brought us closer to understanding the molecular and cell mechanisms responsible for their development. However, these data are not enough for a complete understanding of the genesis of these diseases, nor to suggest treatment methods. It turns out that many cellular pathologies developing during neurodegeneration coincide from disease to disease. These observations give hope to finding a common intracellular target(s) and to offering a universal method of treatment. In this review, we attempt to analyze data on similar cellular disorders among neurodegenerative diseases in general, and polyglutamine neurodegenerative diseases in particular, focusing on the interaction of various proteins involved in the development of neurodegenerative diseases with various cellular organelles. The main purposes of this review are: (1) to outline the spectrum of common intracellular pathologies and to answer the question of whether it is possible to find potential universal target(s) for therapeutic intervention; (2) to identify specific intracellular pathologies and to speculate about a possible general approach for their treatment.

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Section: Huntingtin–protein Interactions As the Basis Of Intracellula...mentioning

confidence: 99%

Huntingtin and Other Neurodegeneration-Associated Proteins in the Development of Intracellular Pathologies: Potential Target Search for Therapeutic Intervention

(Taran)

Shakhov

Kotlobay

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

Microtubule Plus-End Dynamics Visualization in Huntington's Disease Model based on Human Primary Skin Fibroblasts

Cited by 1 publication

References 0 publications

Huntingtin and Other Neurodegeneration-Associated Proteins in the Development of Intracellular Pathologies: Potential Target Search for Therapeutic Intervention

Huntingtin and Other Neurodegeneration-Associated Proteins in the Development of Intracellular Pathologies: Potential Target Search for Therapeutic Intervention

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