Microvessel and mast cell densities in malignant laryngeal neoplasm

Balica, Nicolae Constantin; Ceauşu, Raluca Amalia; Gaje, Pușa Nela; Doros, C; Poenaru, Mărioara

doi:10.2298/abs1403163b

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…In HNSCC, some authors noticed a decrease in mast cell number associated with advanced histological grade in OSCC, other found a significant correlation between mast cells density and G1, G2 histological grade in larynx carcinoma [63,64].…”

Section: The Afferent Stroma Proliferation the Mast Cell Blood Vessmentioning

confidence: 99%

Toward a Molecular Classification of the Head and Neck Squamous Cell Carcinoma

Ceauşu¹,

Boia²,

Boia³

et al. 2021

Surgical Management of Head and Neck Pathologies

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The frequency of the squamous cell carcinoma of the head and neck is constantly increasing, with over 550.000 new cases registered globally each year. The conventional histopathological diagnosis most commonly indicates the squamous cell carcinoma as tumor type and G2 as differentiation grade. Despite of this relative morphological uniformity, there is a great heterogeneity in the molecular profile, the therapeutic response and prognosis. Most probably, this entity includes many diseases, similar in basic morphologic features, but different in the biological behavior. Trying to answer this question and to show discrepancies when they exist, we have evaluated in this book chapter, our own results and data from the literature in terms of molecular profile at the protein level, including the spectrum of proliferation markers, growth factors and their receptors, stromal proliferation, angiogenesis and lymphangiogenesis. These data will allow to identify some major criteria for a better stratification of cases, selected for gene analysis and personalized therapy as a future perspective and direction.

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Section: The Afferent Stroma Proliferation the Mast Cell Blood Vessmentioning

confidence: 99%

Toward a Molecular Classification of the Head and Neck Squamous Cell Carcinoma

Ceauşu¹,

Boia²,

Boia³

et al. 2021

Surgical Management of Head and Neck Pathologies

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show abstract

“…In the last decades, it was shown a significant increase in the number of new cases, and equally important, these tumors are characterized by aggressive behavior and limited survival. Remarkably, most of these tumors are squamous cell carcinomas (SCCs), and in many cases, it is suspected infection with human papillomaviruses [ 3 , 4 ]. Such an infection of the head and neck tissues induces major changes not only in epithelial cells but also in the connective tissue compartment that is lamina propria and it seems to be the origin of the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

The mast cell reaction in premalignant and malignant lesions of the head and neck

Cosoroabă

Gaje²,

Ceauşu³

et al. 2022

Rom J Morphol Embryol

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Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent and aggressive neoplasms of this anatomical region. Many studies evaluated the neoplastic cells, but few works focused on the tumor microenvironment. In the present study, we investigated the distribution and mast cell density (MCD) in malignant and premalignant lesions of the oral cavity, tongue, pharynx, and larynx. There were analyzed 52 specimens of HNSCC, and 15 biopsies taken from patients with dysplasia. Results were compared with those found in a control group of 10 biopsies of oral mucosa from patients with inflammatory diseases. Slides stained with Hematoxylin-Eosin were used for the histopathological diagnosis and grade, and mast cells (MCs) were identified by immunohistochemistry, using anti-MC tryptase. MCs were counted using a method similar to that proposed for microvessel density. We found a significant increase in the number of MCs from the normal oral mucosa until overt carcinoma. Unlike normal tissues, in HNSCC, many MCs were found between tumor cells. We found no relationship between MCs and blood vessels in the tumor area. A significant statistical correlation was found between dysplastic and malignant tumors, but not between tumors with a different grade. Also, it was not found relationship between MCD and the anatomical location of the tumor. Based on these results, we believe that MCD evaluated by anti-MC tryptase is an independent factor of prognosis and reflects an unfavorable outcome.

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Microvessel and mast cell densities in malignant laryngeal neoplasm

Cited by 2 publications

References 19 publications

Toward a Molecular Classification of the Head and Neck Squamous Cell Carcinoma

Toward a Molecular Classification of the Head and Neck Squamous Cell Carcinoma

The mast cell reaction in premalignant and malignant lesions of the head and neck

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