Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma

Abstract

Neovascularization is associated with nodal spread as well as local recurrence and serves as an independent prognostic factor for survival after curative resection of hilar cholangiocarcinoma. Therefore, tumor-associated neovascularization seems to be critically involved in the progression of this tumor entity. In addition, neovascularization may represent a potential target in he development of new therapeutic approaches in hilar cholangiocarcinoma.

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

“…Analysis of tumour-associated neovascularization indicates that angiogenesis occurs in CCA 189 and is critical for its progression [189][190][191][192] . iCCAs with high micro vessel density more frequently display advanced primary tumours and multiple tumour nodes 190 .…”

CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma

“…Intrahepatic cholangiocarcinoma (IHCC) is well known to be one of the most malignant solid tumors in digestive organs [1][2][3][4][5]. We have already reported that lymph node metastases are seldom limited to the regional lymph nodes; most tumor recurrence occurs in the liver.…”

Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas

“…Microvessel synthesis has been considered to influence tumor metastasis and prognosis in various human cancers [19]. Interleukin 8 (IL-8) has received much attention with its role in microvessel synthesis in various tumors [20].…”