Microvessel density is a prognostic marker of human gastric cancer

Zhao, Hua-Lu; Qin, Rong; Chen, Xiaoxin; Sheng, Xia; Wu, Jing; Wang, Daobin; Chen, Guihua

doi:10.3748/wjg.v12.i47.7598

Cited by 48 publications

(47 citation statements)

References 27 publications

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“…Mean microvessel density has been correlated with risk of metastasis, prediction of efficacy of anticancer therapy, and prognosis in a variety of tumour types (Des Guetz et al, 2006;Gadducci et al, 2006;Zhao et al, 2006;Barresi et al, 2007;Calvin et al, 2007;Gulubova and Vlaykova, 2007;Kavantzas et al, 2007;Trivella et al, 2007). The PCI results agree with Eberhard's data (Eberhard et al, 2000).…”

Section: Discussionmentioning

confidence: 56%

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

Gaya

Daley²,

Taylor³

et al. 2008

Br J Cancer

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Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic changes demonstrated by dynamic MRI (DCE-MRI) in response to CA4P, with tumour immunohistochemical angiogenic markers. Tissue was received from 24 patients (mean age 59, range 32 -73, 18 women, 6 men). An angiogenic profile was performed using standard immunohistochemical techniques. Dynamic MRI data were obtained for the same patients before and 4 h after CA4P. Three patients showed a statistically significant fall in K trans following CA4P, and one a statistically significant fall in IAUGC 60 . No statistically significant correlations were seen between the continuous or categorical variables and the DCE-MRI kinetic parameters other than between ang-2 and K trans (P ¼ 0.044). In conclusion, we found no strong relationships between changes in DCE-MRI kinetic variables following CA4P and the immunohistochemical angiogenic profile.

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Section: Discussionmentioning

confidence: 56%

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

Gaya

Daley²,

Taylor³

et al. 2008

Br J Cancer

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“…However, we found that serum VEGF-D levels were higher in the control group than in patients with gastric cancer. George et al [12] studied VEGF-A, -C, and -D mRNA tissue expression in colorectal cancer progression, demonstrating that VEGF-D mRNA remained at persistently low levels in carcinomas compared with adenomas, and that both VEGFR-2 and VEGFR-3 mRNA expression levels remained constant. This result suggested that VEGF-D acts as a competitive agonist with VEGF-A and VEGF-C; a decrease in VEGF-D levels may allow increased access of VEGF-A and VEGF-C, which are more potent angiogenic cytokines than VEGF-D, to the two VEGF receptors [22] .…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown an association between intratumoral microvessel density and tumor aggressiveness in gastric cancer [12,13] . Among angiogenic stimulators, VEGF-A plays an essential role in both vasculogenesis and angiogenesis [14] .…”

Section: Introductionmentioning

confidence: 99%

Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma

Al-Moundhri¹,

Al-Shukaili²,

Al-Nabhani³

et al. 2008

WJG

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AIM:To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A, -C, and -D, and their receptors, VEGFR-1 and -2 in gastric adenocarcinomas. METHODS:The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS:The serum levels of VEGF-A and its receptor, VEGFR-1, were significantly higher in patients with gastric cancer than in healthy donors (t = 2.3, P = 0.02 and t = 4.2, P < 0.0001, respectively). In contrast, the serum levels of VEGF-D were significantly higher in control subjects than in patients (t = 2.9,

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“…The degree of intratumoral microvascular density (MVD) is thought to influence tumor metastasis and consequently prognosis in various human cancers, including gastric cancer [3][4][5][6] . Recent investigations have shown that high expression of integrin β3 is positively correlated with invasion and metastasis of cancer cells and tumor angiogenesis [7,8] , but only a few studies have investigated the relationship between integrin β3 and prognosis of gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Correlation of integrin β3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma

Li¹,

Ye²,

Zhao³

et al. 2008

WJG

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peritoneal metastasis, the mean MVD were significantly higher than those in patients of expanding type (P < 0.01), stage T1-T2 (P < 0.01), non-vessel invasion (P < 0.01), without lymphatic metastasis (P < 0.01), without hepatic and peritoneal metastasis (P < 0.01), respectively. It was found that the positive expression rate of integrin β3 mRNA was positively related to that of VEGF protein (P < 0.01) and MVD (P < 0.05), meanwhile the positive expression rate of VEGF protein was positively related to MVD (P < 0.05). The mean survival period in patients with positive expression of integrin β3 mRNA and VEGF, and MVD ≥ 54.9/mm 2 was significantly shorter than that in patients with negative expression of integrin β3 mRNA (P < 0.05) and VEGF (P < 0.01), and MVD < 54.9/mm 2 (P < 0.01). Five-year survival rate in patients with positive expression of integrin β3 mRNA and VEGF, and MVD ≥ 54.9/mm 2 was significantly lower than those with negative expression of integrin β3 mRNA (P < 0.05), VEGF (P < 0.05), and MVD < 54.9/mm 2 (P < 0.01). CONCLUSION:Integrin β3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of gastric carcinoma. Therefore, they may be prognostic biomarkers and novel molecular therapeutic targets. INTRODUCTIONGastric cancer is the leading cause of death in China. Abstract AIM: To investigate integrin β3 mRNA and vascular endothelial growth factor (VEGF) protein expression in gastric carcinoma, and its correlation with microvascular density, growth-pattern, invasion, metastasis and prognosis. METHODS: In situ hybridization (ISH) of integrin β3mRNA and immunohistochemistry of VEGF and CD34 protein were performed on samples from 118 patients with gastric cancer. RESULTS:The positive rate of integrin β3 mRNA in nontumor gastric mucosa (20%) was significantly lower than that of the gastric cancer tissue (52.5%, χ 2 = 10.20,

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Microvessel density is a prognostic marker of human gastric cancer

Cited by 48 publications

References 27 publications

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

Measurement of circulating levels of VEGF-A, -C, and -D and their receptors, VEGFR-1 and -2 in gastric adenocarcinoma

Correlation of integrin β3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma

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