Microwave-assisted digestion using dilute nitric acid solution and investigation of calibration strategies for determination of As, Cd, Hg and Pb in dietary supplements using ICP-MS

Pinheiro, Fernanda C.; Babos, Diego Victor; Barros, Ariane Isis; Pereira-Filho, Edenir Rodrigues; Nóbrega, Joaquim A.

doi:10.1016/j.jpba.2019.06.018

Cited by 43 publications

(25 citation statements)

References 17 publications

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“…In this analysis, (d i � 1) corresponds to a desired response (maximum analytical signal for all elements), while (d i � 0) represents a minimum analytical signal. Finally, the individual desirability of each analyte was combined into a single response, which means the overall desirability (CD) through the geometric mean [16].…”

Section: Optimization Of the Txrf Variablesmentioning

confidence: 99%

“…e results show that methods TXRF_DS_1 and TXRF_DS_2 are suitable options to quantify without any problem to heavy metals at trace levels, even below the maximum permissible limits imposed by international standards [13][14][15][16]. e TXRF technique is presented as a useful tool for monitoring heavy metals in food supplements, through which the quality of these products can be guaranteed before going to market and consumers ingest them.…”

Section: Analysis Of Real and Spiked Samplesmentioning

confidence: 99%

“…e World Health Organization (WHO) guidelines proposed Pb permissible levels (10 μg•g −1 ) in medicinal raw plant materials and dietary supplements [13], whereas, for plant-based food supplements, the European Commission set limits of 3 μg•g −1 and 0.1 μg•g −1 for Pb and Hg, respectively [14]. e United States Pharmacopeia (USP) recommended permissible limits (in μg•g −1 ) for Pb (0.5), As (0.15), and Hg (1.5) in dietary supplements [15,16]. Besides, the growing interest, popularity, and the lack of quantitative and qualitative research on the composition of supplements before being place into the market are important topics to attend [17].…”

Section: Introductionmentioning

confidence: 99%

“…e most common techniques used for the elemental analysis in dietary supplements include inductively coupled plasma optical emission spectrometry (ICP-OES) [18], inductively coupled plasma mass spectrometry (ICP-MS) [3,19,20], wavelength dispersive-x-ray fluorescence spectrometry (WD-XRF) [16], scanning electron microscopyenergy dispersive x-ray spectrometry (SEM-EDX), and ion chromatography (IC) [21]. However, to our knowledge, there is not any publication about the validation of an analytical method for heavy metals determination in dietary supplements by Total Reflection X-ray Fluorescence Spectroscopy (TXRF).…”

Section: Introductionmentioning

confidence: 99%

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Total Reflection X-Ray Fluorescence Spectroscopy (TXRF) Method Validation: Determination of Heavy Metals in Dietary Supplements

Beltrán

Ramos-Sánchez

Chávez‐Flores

et al. 2020

Journal of Chemistry

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Dietary supplements may contain heavy metals with the property of bioaccumulation in humans. The aim of this research was to validate and apply two analytical methods to determine Pb, As, Cr, and Hg in dietary supplements by Total Reflection X-ray Fluorescence Spectroscopy (TXRF). Methods validation was conducted through a multivariate analysis using a central composite design (CCD) and a desirability function. Critical values for each study variable were established. The TXRF_DS_1 method was proposed for Pb, As, and Cr determinations, while the TXRF_DS_2 was established for Hg analysis. The digestion method with an acid mixture (HNO3 + HCl + H2O2) was used to break down the organic material of dietary supplements. A solution of 10 μg L−1 Ga was used as an internal standard. Excellent analytical performance was obtained as LODs of 0.59, 0.41, 0.57, and 0.75 μg L−1 and LOQs of 1.95, 1.35, 1.90, and 2.50 μgL −1 for Pb, As, Cr, and Hg, respectively. Calibration curves showed a good linearity for all elements (R2>0.999). Excellent accuracy and precision in measurements (% RSD) was achieved. The real and spiked samples analysis demonstrated the applicability of the TXRF technique (percentage recovery 91–108%). Besides, two samples were analyzed in a comparison study between the TXRF_DS_1 method and the ICP-OES method. The results obtained showed good agreement between both techniques. The TXRF technique allows the analysis of toxic heavy metals in dietary supplements, which are marketed in a wide variety of presentations.

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Section: Optimization Of the Txrf Variablesmentioning

confidence: 99%

Section: Analysis Of Real and Spiked Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Total Reflection X-Ray Fluorescence Spectroscopy (TXRF) Method Validation: Determination of Heavy Metals in Dietary Supplements

Beltrán

Ramos-Sánchez

Chávez‐Flores

et al. 2020

Journal of Chemistry

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“…Although there are methods to digest complex compounds such as rubber using microwaves, it requires a high amount of acids. Alternative methods using moderate amounts of acids are needed to ful ll the green chemistry requirements [24].…”

Section: Introductionmentioning

confidence: 99%

Desulfurization of Vulcanized Rubber Particles Using Biological and Chemical Methods

Valdés¹,

Hernández²,

Morales-Vera³

et al. 2020

Preprint

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Currently, recycling or degradation treatments for tires are an enormous challenge. Despite efforts to dispose of or recycle it, rubber waste is increasing year by year worldwide. To create a rubber-recycling system, several researchers have proposed tire desulfurization. In this study, we compare two methods: one biological, using Acidobacillus ferroxidans in shake 250 mL flask experiments, and one chemical using, for the first time, microwaves and an aqueous solution. The results of these methods were analyzed through sulfate quantification, cross-linking differences, Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy with energy disperse spectroscopy (SEM-EDS). We observed that the amount of sulfates generated by the chemical system was 56 mg / L, which was 10-times higher than the biological system, which generated 5.3 mg / L. Similarly, after cross-linking studies, a 36% higher decrease after the chemical treatment was observed. When using FTIR analysis, the disappearance of characteristic bands corresponding to functional groups containing sulfur bonds was observed by treating the sample with both desulfurization mechanisms. Morphological changes on the rubber surface structure was also demonstrated by SEM-EDS analysis with the appearance of holes, cracks and changes in the porosity of the material. This work analyzed two different non-aggressive desulfurization mechanisms that might be used as sustainable methods for rubber recycling processes.

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Terahertz for Tracking the Cadmium Heavy Metal Accumulation During Pak Choi (Brassica chinensis) Food Production Processes

Zhao,

Gouda,

Lin

et al. 2024

Methods and Protocols in Food Science

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Microwave-assisted digestion using dilute nitric acid solution and investigation of calibration strategies for determination of As, Cd, Hg and Pb in dietary supplements using ICP-MS

Cited by 43 publications

References 17 publications

Total Reflection X-Ray Fluorescence Spectroscopy (TXRF) Method Validation: Determination of Heavy Metals in Dietary Supplements

Total Reflection X-Ray Fluorescence Spectroscopy (TXRF) Method Validation: Determination of Heavy Metals in Dietary Supplements

Desulfurization of Vulcanized Rubber Particles Using Biological and Chemical Methods

Terahertz for Tracking the Cadmium Heavy Metal Accumulation During Pak Choi (Brassica chinensis) Food Production Processes

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