Microwave-Assisted Synthesis of Tetrazole Based Biphenyls Derivatives and Their Antimicrobial Activity

Abstract

An environmentally friendly method has been developed for substituted (E)-(3-(4-(1H-tetrazole-5yl)styryl)benzofuran-2-yl)([1,1'-biphenyl]-4-yl)methanone scaffolds by Suzuki cross-coupling reaction in an aqueous medium under both microwave irradiation and conventional heating methods. The structures of the synthesized scaffolds were characterized by IR, NMR, and mass spectral analysis. Furthermore, the synthesized scaffolds were screened for their in-vitro antibacterial, antifungal activities and most of the scaffolds exhibited better activity compared to standard drugs.