Microwave-Induced Thermoacoustic Imaging for Embedded Explosives Detection in High-Water Content Medium

Wang, Xiong; Qin, Tao; Qin, Yexian; Abdelrahman, Ahmed H.; Witte, Russell S.; Xin, Hao

doi:10.1109/tap.2019.2908267

Cited by 25 publications

(4 citation statements)

References 54 publications

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“…In biomedical imaging, MTAI is widely used in anatomical, functional, molecular, and histological studies due to its high resolution, deep imaging depth and minimal biohazards. Patch et al [29][30][31][32][33][34], Kruger et al [5,[35][36][37][38][39][40][41][42], Xing et al [11,17,[43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58], Wang et al [12,13,15,16,[59][60][61][62][63][64][65][66], Jiang et al [4,[67][68][69][70]…”

Section: Introductionmentioning

confidence: 99%

Microwave-induced thermoacoustic imaging for biomedical applications

et al. 2023

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Microwave-induced thermoacoustic imaging (MTAI) is an emerging physical imaging technology that combines the high resolution of ultrasound imaging with the high contrast of microwave imaging and the advantages of deep penetration of microwave. MTAI uses microwave as the excitation source and ultrasound as the information carrier, through the transformation of microwave to ultrasound energy transfer form to achieve non-destructive, high-resolution imaging of biological tissue at a depth of centimetres. The contrast of MTAI image is determined by the difference of microwave absorption. In biological tissues, polar molecules such as water molecules (molecular polarization loss) and ions (ion polarization loss) are mainly used as signal sources to obtain structural and functional images of biological tissues. After more than 20 years of development, MTAI has been applied to imaging various biological tissues and detecting multiple diseases, such as brain imaging, breast imaging, joint imaging, prostate cancer detection, cerebral hemorrhage detection, etc. This paper provides a comprehensive review on: (1) the principle of MTAI, (2) application in the biomedical field, and (3) future development direction.

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Section: Introductionmentioning

confidence: 99%

Microwave-induced thermoacoustic imaging for biomedical applications

et al. 2023

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“…The recent rise in global terrorism means that the use of these methods to detect explosives should be both sensitive and low cost. Trained bees [2], sniffer dogs [3], surface-enhanced Raman spectroscopy [4,5], mass spectroscopy [6], X-ray imaging [7], thermal neutron analysis [8] and microwave-induced thermoacoustic imaging [9] have been proposed as suitable methods for the detection of these explosives. Although all of the abovementioned methods offer advantages, there are many improvements to be made to the response speed, cost, sensitivity and in-field applications of explosive sensors [10,11].…”

Section: Introductionmentioning

confidence: 99%

Sensitive Evanescence-Field Waveguide Interferometer for Aqueous Nitro-Explosive Sensing

Wang

Deng

et al. 2023

Chemosensors

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The development of novel chemical nitro-explosive sensors with high sensitivity, low cost and a compact size is essential for homeland security, environmental protection and addressing military challenges. Polymeric optical waveguides based on refractive index sensing are widely used in biochemical detection due to their advantages of large-scale integration, low cost, high sensitivity and anti-electromagnetic interference. In this study, we designed and fabricated a polymer waveguide Mach–Zehnder interferometer (MZI) sensor to detect 2,4-dinitrotoluene (DNT) in water. One phase shifter of the MZI waveguide was functionalized by coating a thin cladding layer of polycarbonate with dipolar chromophores and used as the sensing arm; the other arm was coated with passive epoxy resin cladding and used as the reference arm. The phase difference between the two arms of the MZI was modulated using the refractive index (RI) change in the polycarbonate cladding when dipolar chromophores interacted with electro-deficient DNT. The theoretical sensitivity of the designed MZI can reach up to 24,696 nm/RIU. When used for explosive detection, our fabricated sensor had a maximum wavelength shift of 4.465 nm and good linear relation, with an R2 of 0.96 between the wavelength shift and a concentration ranging from 3.5 × 10−5 to 6.3 × 10−4 mol/L. The sensitivity of our device was 6821.6 nm/(mol/L). The design of an unbalanced MZI sensor, together with the sensing material, provides a new approach to using low-cost, compact and highly sensitive devices for in-field explosive detection.

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“…Microwave-induced thermoacoustic tomography (TAT) utilizes pulsed microwaves to generate ultrasonic signals. [12][13][14][15][16][17][18][19] As a hybrid modality, TAT combines the advantages of high electromagnetic contrast and high ultrasonic resolution. In recent years, TAT has been developed in many aspects, such as thermoacoustic mesoscopy, compressive sensing TAT, thermoacoustic endoscopy, multimodality imaging, thermoacoustic molecular imaging, and low-cost portable TAT systems.…”

Section: Introductionmentioning

confidence: 99%

“…Microwave‐induced thermoacoustic tomography (TAT) utilizes pulsed microwaves to generate ultrasonic signals 12–19 . As a hybrid modality, TAT combines the advantages of high electromagnetic contrast and high ultrasonic resolution.…”

Section: Introductionmentioning

confidence: 99%

First assessment of thermoacoustic tomography for in vivo detection of rheumatoid arthritis in the finger joints

Chi

Huang

et al. 2021

Medical Physics

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Background: The diagnosis of rheumatoid arthritis (RA) is complicated because of the complexity of symptoms and joint structures. Current clinical imaging techniques for the diagnosis of RA have strengths and weaknesses. Emerging imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of RA.Purpose: This study aimed to demonstrate the potential of thermoacoustic tomography (TAT) for in vivo detection of RA in the finger joints. Methods: Finger joints were imaged by a TAT system using three different microwave illumination methods including pyramidal horn antenna, and parallel in-phase and anti-phase microwave illuminations. Both diseased and healthy joints were imaged and compared when the three microwave illumination methods were used. Magnetic resonance imaging (MRI) of all the joints was performed to validate the TAT findings. In addition, two diseased joints were imaged at two time points by the pyramidal horn antenna-based TAT to track/monitor the progression of RA during a time period of 16 months. Three-dimensional (3-D) TAT images of the joints were also obtained. Results:The TAT images of the diseased joints displayed abnormalities in bone and soft tissues compared to the healthy ones. The TAT images by pyramidal horn antenna and in-phase microwave illumination showed high similarity in image appearance, while the anti-phase-based TAT images provided different information about the disease. We found that the TAT findings matched well with the MRI images. The 3-D TAT images effectively displayed the stereoscopic effect of joint lesions. Finally, it was evident that TAT could detect the development of the lesions in 16 months. Conclusion: TAT can noninvasively visualize bone lesions and soft tissue abnormalities in the joints with RA. This first in vivo assessment of TAT provides a foundation for its clinical application to the diagnosis and monitoring of RA in the finger joints.

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Microwave-Induced Thermoacoustic Imaging for Embedded Explosives Detection in High-Water Content Medium

Cited by 25 publications

References 54 publications

Microwave-induced thermoacoustic imaging for biomedical applications

Microwave-induced thermoacoustic imaging for biomedical applications

Sensitive Evanescence-Field Waveguide Interferometer for Aqueous Nitro-Explosive Sensing

First assessment of thermoacoustic tomography for in vivo detection of rheumatoid arthritis in the finger joints

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