Microwave therapy for cutaneous human papilloma virus infection

Bristow, Ivan; Lim, Wen Chean; Lee, Alvin; Holbrook, Daniel James; Savelyeva, Natalia; Thomson, Peter; Webb, Christopher; Polak, Marta E.; Ardern‐Jones, Michael R.

doi:10.1684/ejd.2017.3086

Cited by 23 publications

(49 citation statements)

References 28 publications

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“…In future studies, adopting a stepwise overlapping delivery of treatment across the whole surface of the AK might lead to higher rates of complete resolution. This approach has been used successfully for plantar warts . Seven per cent of untreated AKs had spontaneously resolved by visit 11, which is similar to that reported in other studies and demonstrates the importance of an internal control.…”

Section: Discussionsupporting

confidence: 83%

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A feasibility study of microwave therapy for precancerous actinic keratosis

et al. 2020

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Summary Background Actinic keratosis (AK) is a common premalignant skin lesion that can progress to cutaneous squamous cell carcinoma (cSCC). Microwave therapy is an established cancer treatment and has been used for plantar viral warts. Objectives To evaluate the efficacy and feasibility of microwave as a treatment for AK. Methods Stage I was a dose‐setting study, in which seven participants had the dielectric properties of 12 thick and 22 thin AKs assessed for optimization of the microwave dose used for treatment in Stage II. Stage II was a randomized, internally controlled trial evaluating 179 AKs in 11 patients (93 treated, 86 untreated controls) on the scalp/forehead or dorsal hand. Participants received one treatment initially and a repeat treatment to unresolved AKs at week 4. The response was assessed at six visits over 4 months. The primary outcome was partial or complete resolution of the treated AKs. Results A significantly higher proportion of treated AK areas responded than untreated (90% vs. 15%; P < 0·001). Thin AKs were more responsive than thick AKs. The site did not affect efficacy. Pain was severe, but brief (80% reported pain lasting ‘a few seconds only’). Adverse effects were minimal (erythema, n = 6; flaking, n = 3; itch, n = 3). All participants who would chose microwave therapy over their current treatment cited the shorter discomfort period. Conclusions Microwave therapy is a portable, safe and effective treatment for AK. An easy‐to‐deliver, acceptable therapy for AK is attractive as a prevention strategy. While these results are promising, a larger randomized controlled trial is needed against an effective comparator to confirm clinical efficacy and patient acceptability. What is already known about this topic? Actinic keratoses (AKs) are common precancerous skin lesions. Successful treatment of AK can prevent cutaneous squamous cell carcinoma (cSCC). Most topical therapies for AK require repeated application over weeks and drive local skin inflammation, leading to poor compliance. An easy‐to‐deliver and effective treatment for AK, suitable for use in primary care, could reduce cSCC. What does this study add? Microwave therapy is a feasible, effective treatment for AK. Ninety per cent of treated AKs showed full or partial resolution at 120 days post‐treatment. Microwave therapy was painful, but the pain was short‐lived (seconds) and this short discomfort period was cited as the main reason that microwave was preferred to their current treatment. Linked Comment: Samimi and Kelleners-Smeets. Br J Dermatol 2020; 183:197–199.

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Section: Discussionsupporting

confidence: 83%

“…Microwave therapies are established within oncology for ablative treatment of internal malignancies . Microwave energy has shown promise in the treatment of recalcitrant plantar viral warts . This study used a CE‐marked microwave medical device (Swift ® Microwave Tissue Ablation System, Emblation Ltd, Alloa, UK).…”

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confidence: 99%

A feasibility study of microwave therapy for precancerous actinic keratosis

et al. 2020

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“…Preliminary studies of human skin explants exposed to low-level microwave energy suggested that increased danger signalling in keratinocytes, including induction of HSP70, may be the critical pathway for cutaneous wart resolution. Microwave-treated keratinocytes were able to induce dendritic cell activation (CD80, CD86, CD40) and enhancement of anti-HPV responses by CD8+ T cells [ 12 , 13 ]. This case study represents an exciting additional therapeutic option for treatment of recalcitrant cutaneous warts.…”

Section: Discussionmentioning

confidence: 99%

The Successful Use of a Novel Microwave Device in the Treatment of a Plantar Wart

Bristow¹,

Webb²,

Ardern‐Jones³

2017

Case Rep Dermatol

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Plantar warts, caused by the human papilloma virus (HPV), are a commonly encountered condition presenting in clinic. In adults, an array of various therapies exists, frequently with modest results particularly with plantar lesions. Microwaves have had limited uses for medical purposes. Recently a new portable microwave device has been approved for the treatment of skin lesions. Prior research has demonstrated immuno-stimulatory effects against HPV infection. We report the application of a novel portable medical microwave unit to treat a long-standing plantar wart which had failed to respond to other treatment modalities.

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“…In eqs. (14), (15) The final solution for the secondary field inside the sphere and in particular for the total pressure is obtained to be:…”

Section: The Field Expression Inside the Sphere Rmentioning

confidence: 99%

“…It is observed that under physiological conditions of salinity and acidity, virus capsid assembly requires the presence of genomic material that is oppositely charged to the core proteins 10 . Furthermore, few researchers have focused their research on the possibility of inducing photon-phonon interactions 11 in virions, which are the virus causing infections 12,13,14,15,16,17 .…”

Section: Introductionmentioning

confidence: 99%

Theoretical Analysis of the Induction of Forced Resonance Mechanical Oscillations to Virus Particles by Microwave Irradiation:Prospects as an Anti-virus Modality

Uzunoglu¹

2020

Preprint

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The induction of acoustic-mechanical oscillations to virus particles by illuminating them with microwave signals is analyzed theoretically. Assuming the virus particle being of spherical shape, its capsid consisting primarily of glycoproteins, a viscous fluid model is adopted while the outside medium of the sphere is taken to be ideal fluid. The electrical charge distribution of virus particle is assumed to be spherically symmetric with a variation along the radius. The generated acoustic-mechanical oscillations are computed by solving a boundary value problem analytically, making use of the Green’s function approach. Resonance conditions to achieve maximum energy transfer from microwave radiation to acoustic oscillation to the particle is investigated. Estimation of the feasibility of the technique to compete virus epidemics either for sterilization of spaces and/or use for future therapeutic applications is examined briefly.

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Microwave therapy for cutaneous human papilloma virus infection

Cited by 23 publications

References 28 publications

A feasibility study of microwave therapy for precancerous actinic keratosis

A feasibility study of microwave therapy for precancerous actinic keratosis

The Successful Use of a Novel Microwave Device in the Treatment of a Plantar Wart

Theoretical Analysis of the Induction of Forced Resonance Mechanical Oscillations to Virus Particles by Microwave Irradiation:Prospects as an Anti-virus Modality

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