Mid-Phase Hyperfluorescent Plaques Seen on Indocyanine Green Angiography in Patients with Central Serous Chorioretinopathy

Bousquet, Elodie; Provost, Julien; Zola, Marta; Spaide, Richard F.; Béhar-Cohen, Francine

doi:10.3390/jcm10194525

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…Vascular remodeling in the context of venous overload may also predispose to CNV occurrence [ 28 ]. Other authors have postulated that pachyvessels develop when there is increased choroidal perfusion, which promotes oxidative stress, Bruch’s membrane injury, and diffuse RPE changes, usually seen above mid-phase hyperpermeability plaques [ 29 ]. In eyes with long-lasting CSCR, the CNV is frequently silent for several years and is only diagnosed when OCT-A is performed [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

OCT Angiography Fractal Analysis of Choroidal Neovessels Secondary to Central Serous Chorioretinopathy, in a Caucasian Cohort

Serra

Pinna

Béhar-Cohen

et al. 2022

JCM

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Central serous chorioretinopathy (CSCR) can be complicated by different types of choroidal neovascularization (CNV). The purpose of this study was to investigate the incidence and quantitative optical coherence tomography angiography (OCT-A) features of CSCR-related CNVs. Methods: This was a retrospective multicenter study including 102 eyes of 102 Caucasian patients with acute or complex CSCR. All patients underwent a comprehensive ophthalmological examination. Quantitative OCT-A parameters, including vascular perfusion density (VPD), fractal dimension (FD), and lacunarity (LAC), were measured in CNV eyes. Results: Forty eyes (39.2%) had acute CSCR, whereas the remaining sixty-two (60.8%) had complex CSCR. CNV was observed in 37 (36.27%) eyes, all of which had the complex form. CNVs were classified as type 1 CNV in 11/37 (29.73%) cases and as polypoidal choroidal vasculopathy (PCV) in the remaining 26/37 (70.27%). Overall, the mean VPD, FD, and LAC of CSCR-related CNVs were 0.52 ± 0.20%, 1.44 ± 0.12, and 2.40 ± 1.1, respectively. No significant difference between type 1 CNV and PCV was found. Conclusion: Complex CSCR is often complicated by type 1 CNV and PCV with similar neovascular architecture and branching complexity, a finding supporting the idea that they might be different stages of the same neovascular process. Future OCT-A fractal analysis-based studies that also include other relevant parameters, such as demographics, presentation, morphology on multimodal imaging, and response to treatment, are necessary before drawing any definitive conclusions.

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Section: Discussionmentioning

confidence: 99%

OCT Angiography Fractal Analysis of Choroidal Neovessels Secondary to Central Serous Chorioretinopathy, in a Caucasian Cohort

Serra

Pinna

Béhar-Cohen

et al. 2022

JCM

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“…Interestingly, the rate of hyperfluorescent plaques corresponding to choroidal hyperpermeability on mid-phase angiography was lower in women than in men. We have recently shown that these plaques could correspond to an early sign of epitheliopathy secondary to choroidal hyperpermeability [ 27 ]. Altogether, these findings demonstrated that RPE damage is less extensive in women than in men.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Multimodal Imaging Findings of Central Serous Chorioretinopathy in Women versus Men

Bousquet

Torres-Villaros

Provost

et al. 2022

JCM

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(1) The aim of this study was to compare the clinical characteristics and multimodal imaging findings of central serous chorioretinopathy (CSCR) between women and men. (2) Women and men with CSCR were compared in terms of their age and risk factors, the clinical form of their disease, multimodal imaging findings and the presence of macular neovascularization (MNV) on optical coherence tomography (OCT)-angiography. (3) Results: The data of 75 women and 75 men were compared. The women were significantly older than the men (52.2 years versus 45.7 years; p < 0.001). Corticosteroid intake was more frequent in the women (56% versus 40%; p = 0.05). The women had a single foveal subretinal detachment more often than the men (73.3% versus 46.9%; p < 0.001) and they often had fewer gravitational tracks (16.3% versus 29.6%; p = 0.03). On mid-phase indocyanine green angiography, hyperfluorescent plaques were detected less often in the women than in the men (48% versus 72.2%, p = 0.001). MNV was detected on OCT-angiography in 35.9% of the women and in 13.3% of the men (p = 0.004). (4) In the women, CSCR occurs at an older age, is more often unifocal foveolar, and is associated with a higher rate of MNV. The reasons for these gender-related differences remain to be determined.

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“…Additionally, a breakdown of the outer blood-retina barrier at the level of the RPE occurs, which leads to an accumulation of subretinal fluid (SRF) [ 1 , 2 , 4 ]. This extravasation of the inner choroidal layers can be seen during indocyanine green angiography (ICGA) of affected eyes [ 5 , 6 ]. Hyperpermeability seems to be a crucial factor for the pathogenesis of CSCR.…”

Section: Background and Objectivementioning

confidence: 99%

Morphometric analyses in patients treated with subthreshold laser photocoagulation for central serous chorioretinopathy

et al. 2022

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Background and objective To analyze changes in selected parameters in optical coherence tomography (OCT) after subthreshold laser coagulation (ST-LP) in patients with central serous chorioretinopathy (CSCR). Materials and methods Fifty-four eyes of 49 patients with CSCR were included in the study. Each patient underwent therapy with ST-LP with a frequency-doubled Neodym-YAG Laser and OCT imaging. In OCT the thickness of the central subfield, cube volume, average cube thickness, volume under the ETDRS grid, and average thickness under the ETDRS grid were collected. Results Decreases in total OCT volume and central retinal subfield thickness were statistically significant (p < 0.05). Possible correlations were observed between visual acuity at V3 (3 months after ST-LP) and Baseline and between central retinal subfield thickness at V1 (4 weeks after ST-LP) and visual acuity at BL. Conclusion A decrease in retinal thickness and retinal volume could be shown after ST-LP. Central retinal subfield thickness measured by OCT could be a more sensitive measure than mean retinal thickness or macular volume for early detection of disease recurrence occurring in some patients 3 months after ST-LP.

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Mid-Phase Hyperfluorescent Plaques Seen on Indocyanine Green Angiography in Patients with Central Serous Chorioretinopathy

Cited by 13 publications

References 31 publications

OCT Angiography Fractal Analysis of Choroidal Neovessels Secondary to Central Serous Chorioretinopathy, in a Caucasian Cohort

OCT Angiography Fractal Analysis of Choroidal Neovessels Secondary to Central Serous Chorioretinopathy, in a Caucasian Cohort

Clinical Characteristics and Multimodal Imaging Findings of Central Serous Chorioretinopathy in Women versus Men

Morphometric analyses in patients treated with subthreshold laser photocoagulation for central serous chorioretinopathy

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