2015
DOI: 10.1158/1535-7163.mct-14-0226
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Midkine Lacking Its Last 40 Amino Acids Acts on Endothelial and Neuroblastoma Tumor Cells and Inhibits Tumor Development

Abstract: Midkine (MDK) is a member of a new family of neurotrophic factors considered as rate-limiting growth and angiogenic factors implicated in the onset, invasion, and metastatic process of neuronal tumors, including neuroblastoma. We showed that all neuroblastoma cell lines highly expressed MDK, indicating that it is a critical player in tumor development, which may henceforth represent an attractive therapeutic target. We showed that the knockdown of MDK expression by siRNA led to a marked and significant decreas… Show more

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Cited by 5 publications
(1 citation statement)
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“…For GFP staining, images were taken and analyzed using ImageJ software to determine the area of lung metastasis. To quantify the number of intra-tumoral vessels in 4T1 tumors, paraffin sections were prepared by murine CD34 immunostaining as previously described [50]. Digital images of immunohistochemically stained tissue slides were obtained at ×20 magnification using a slide scanner (NanoZoomer 2.0-HT, Hamamatsu, Japan).…”
Section: Immuno-histochemistrymentioning
confidence: 99%
“…For GFP staining, images were taken and analyzed using ImageJ software to determine the area of lung metastasis. To quantify the number of intra-tumoral vessels in 4T1 tumors, paraffin sections were prepared by murine CD34 immunostaining as previously described [50]. Digital images of immunohistochemically stained tissue slides were obtained at ×20 magnification using a slide scanner (NanoZoomer 2.0-HT, Hamamatsu, Japan).…”
Section: Immuno-histochemistrymentioning
confidence: 99%