Midnight Siesta and Circadian Rhythms of Related Metabolic and Behavioral Variables in Aging Mice

Тимченко, А. С.

doi:10.4172/2325-9590.1000143

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Physiological Mechanism Of Co2 Action1

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2022

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“…In total, Vco2 decreases by more than two times at high (8-10%) CO2 concentrations in the respiratory mixture. At the same time, it is hypercapnia that has a greater metabolic inhibitory effect, since when hypercapnia is created, Vco2 in an experiment on mice immediately decreases by almost two times, but such a decrease does not occur during hypoxia [5,6].…”

Section: Physiological Mechanism Of Co2 Actionmentioning

confidence: 99%

Therapeutic hypercapnia. Review

Tolstun

Muradian

Bezrukov

2022

A&L

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In recent years, interest in hypercapnia and its practical applications has grown significantly. An analysis of literature data shows a wide range of systemic and local applications. Due to its powerful effect on blood circulation, vascular elasticity, activation of angiogenesis, and inhibition of pro-inflammatory factors, hypercapnia is already used in dermatology, phlebology, and therapy. Wide opportunities open up for practical use in neurology, given the powerful neuroprotective effect of carbon dioxide, which not only increases tolerance to ischemia, preventing the development of diseases but can also become a tool for the treatment of stroke and heart attack. The antitumor effect and the ability to reduce the level of metabolic processes also make hypercapnia an attractive geroprotector that will help in solving the issue of life extension. Keywords: hypercapnia; hypoxia; cancer; diabetes; neuroprotection; longevity; carboxytherapy; ischemia; stroke

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Section: Physiological Mechanism Of Co2 Actionmentioning

confidence: 99%