MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case–control study

Du, Guoli; Luo, Jun‐Yi; Wang, Duolao; Li, Yanhong; Fang, Binbin; Li, Xiaomei; Gao, Xiao‐Ming; Yang, Yi‐Ning

doi:10.1038/s41598-019-56949-z

Cited by 13 publications

(9 citation statements)

References 34 publications

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“…Our results are in good agreement with data of other groups indicating that high production of MIF is correlated with an increased susceptibility for a large number of inflammatory and metabolic diseases including chronic kidney failure [75][76][77][78][79]. However, in renal pathologies, MIF seems to act according to a model of antagonistic pleiotropism, in fact, in different clinical situations and in different stages of renal pathology it can exert both harmful and protective effects [47] which can be likened to the story of Dr. Jekyll and Mr. Hyde.…”

Section: Discussionsupporting

confidence: 92%

MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)

Guarneri

Scola

Giarratana

et al. 2022

Genes

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Chronic kidney disease (CKD) is characterized by an increased risk of kidney failure and end-stage renal disease (ESRD). Aging and comorbidities as cardiovascular diseases, metabolic disorders, infectious diseases, or tumors, might increase the risk of dialysis. In addition, genetic susceptibility factors might modulate kidney damage evolution. We have analyzed, in a group of ESRD patients and matched controls, a set of SNPs of genes (Klotho rs577912, rs564481, rs9536314; FGF23 rs7955866; IGF1 rs35767; TNFA rs1800629; IL6 rs1800795; MIF rs755622, rs1007888) chosen in relation to their possible involvement with renal disease and concomitant pathologies. Analysis of the raw data did indicate that IL6 rs180795 and MIF rs755622 SNPs might be markers of genetic susceptibility to ESRD. In particular, the C positive genotypes of MIF rs755622, (dominant model) seem to be an independent risk factor for ESDR patients (data adjusted for age, gender, and associated pathologies). Stratifying results according to age MIF rs755622 C positive genotype frequencies are increased in both the two age classes considered (<59 and ≥59-year-old subjects). Analyses of data according to gender allowed us to observe that ESRD women shoved a significantly reduced frequency of genotypes bearing IL6 rs180795 C allele. In addition, MIF rs755622 might interact with diabetes or hypercholesterolemia in increasing susceptibility to ESRD. In conclusion, our data indicate that some polymorphisms involved in the regulation of both renal function and inflammatory response can influence the evolution of chronic kidney disease and suggest that the modulation of the activities of these and other genes should also be considered as therapeutic targets on to intervene with innovative therapies.

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Section: Discussionsupporting

confidence: 92%

MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)

Guarneri

Scola

Giarratana

et al. 2022

Genes

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“…In the present study, we observed that plasma MIF level was significantly elevated in CAD patients carrying of MIF gene rs755622 CC genotype. This finding was similar to our previous study, which showed MIF levels in ACS patients with CC genotype was significantly higher than ACS patients carrying GG genotype of MIF gene rs755622 41 . Ji et al 40 also reported that the plasma MIF level was higher in MIF rs755622 C allele carriers than in G allele carriers.…”

Section: Discussionsupporting

confidence: 92%

“…The MONICA/KORA Augsburg study suggested that rs755622 C allele and rs2070766 G allele were related to the higher risk for CAD in German females after 10 years follow-up 10 . Another case–control study showed that MIF gene rs755622 C allele was also associated with increased risk of ACS in a Chinese Han population 41 . Our previous study which conducted in a Kazakh population, a Chinese minority ethnic, found that the frequencies of MIF rs755622 CC genotype and C allele were significantly higher in CAD patients than that in control subjects 42 .…”

Section: Discussionmentioning

confidence: 99%

Association between MIF gene promoter rs755622 and susceptibility to coronary artery disease and inflammatory cytokines in the Chinese Han population

Luo

Fang

et al. 2021

Sci Rep

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Macrophage migration inhibitory factor (MIF) is an essential mediator of atherosclerotic plaque progression and instability leading to intracoronary thrombosis, therefore contributing to coronary artery disease (CAD). In this study, we investigated the relationship between MIF gene polymorphism and CAD in Chinese Han population. Three single nucleotide polymorphisms (SNP, rs755622, rs1007888 and rs2096525) of MIF gene were genotyped by TaqMan genotyping assay in 1120 control participants and 1176 CAD patients. Coronary angiography was performed in all CAD patients and Gensini score was used to assess the severity of coronary artery lesions. The plasma levels of MIF and other inflammatory mediators were measured by ELISA. The CAD patients had a higher frequency of CC genotype and C allele of rs755622 compared with that in control subjects (CC genotype: 6.5% vs. 3.9%, P = 0.008, C allele: 24.0% vs. 20.6%, P = 0.005). The rs755622 CC genotype was associated with an increased risk of CAD (OR: 1.804, 95%CI: 1.221–2.664, P = 0.003). CAD patients with a variation of rs755622 CC genotype had significantly higher Gensini score compared with patients with GG or CG genotype (all P < 0.05). In addition, the circulating MIF level was highest in CAD patients carrying rs755622 CC genotype (40.7 ± 4.2 ng/mL) and then followed by GC (37.9 ± 3.4 ng/mL) or GG genotype (36.9 ± 3.7 ng/mL, all P < 0.01). Our study showed an essential relationship between the MIF gene rs755622 variation and CAD in Chinese Han population. Individuals who carrying MIF gene rs755622 CC genotype were more susceptible to CAD and had more severe coronary artery lesion. This variation also had a potential influence in circulating MIF levels.

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“…All the recruited participants were from Urumqi, excluding the surrounding and prefecture area. The design scheme of the study has been previously reported (24).…”

Section: Study Design and Populationmentioning

confidence: 99%

MALAT1 gene rs600231 polymorphism positively associated with acute coronary syndrome in Chinese population: a case-control study

Song¹,

Luo²,

Zhao³

et al. 2021

Cardiovasc Diagn Ther

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Background: Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recognized as a major player in the pathogenesis of coronary artery disease (CAD). The aim of the study was to determine the association between polymorphisms of the MALAT1 gene and acute coronary syndrome (ACS) in a Chinese population in Xinjiang.Methods: In the case-control study, we genotyped three nucleotide polymorphisms (rs3200401, rs4102217, rs600231) of the MALAT1 gene using SNPscan TM typing assays (1,053 controls and 929 ACS patients).Furthermore, we explored a predictive model using MALAT1 rs600231 and clinical variables to predict the risk of ACS. Finally, the relative expression of long noncoding RNA (lncRNA) MALAT1 was also measured in 92 ACS patients and 92 controls using quantitative real-time polymerase chain reaction (qRT-PCR).Results: The prevalence of the GG genotype of rs600231 in ACS group was higher than that in control group (15.7% vs. 14.7%, P=0.048). The dominant model differed (AG + GG vs. AA) and the G allele of rs600231 in ACS group was higher than that in control group (for dominant model: 66.2% vs. 60.9%, P=0.014; for allele: 41.0% vs. 37.8%, P=0.042). Multivariate logistic regression analysis and the predictive nomogram model showed that the dominant model of rs600231 remained an independent risk factor for ACS [odds ratio (OR) =1.32, 95% confidence interval (CI): 1.07-1.63, P=0.009]. The area under the receiver operating characteristic (ROC) curve (AUC) for the nomogram model for the prediction of ACS was 0.738 (95% CI: 0.716-0.761). In addition, in the AG and GG phenotypes, the relative expression of lncRNA MALAT1 was significantly higher in ACS patients than in controls with the same phenotypes (P<0.05).Among ACS group, compared to other genotype carriers, the relative expression level of MALAT1 in GG genotype carriers was higher (P<0.05). Conclusions:The present study suggested that the AG and GG genotype of rs600231 in MALAT1 gene was independently associated with ACS, and could be a risk genetic marker of ACS in a Chinese population in Xinjiang.

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MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case–control study

Cited by 13 publications

References 34 publications

MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)

MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)

Association between MIF gene promoter rs755622 and susceptibility to coronary artery disease and inflammatory cytokines in the Chinese Han population

MALAT1 gene rs600231 polymorphism positively associated with acute coronary syndrome in Chinese population: a case-control study

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