Mifepristone (RU 486) compared with high‐dose estrogen and progestogen for emergency postcoital contraception

Emergency contraception: Knowledge and attitudes of Turkish nursing and midwifery students

“…In 1974, Professor Albert Yuzpe suggested a regimen that consisted of 100 mg ethinyl oestradiol and either 1 mg norgestrel or 0.5 mg levonorgestrel (LNG) taken within 72 h of unprotected intercourse and repeated 12 h later 2 . Progestin-only preparations are also used for EC 3 . The copper-T intrauterine contraceptive device (IUCD) offers an alternative; it should be inserted within 5 days of unprotected sex or, beyond this limit, within 5 days after ovulation, when the time of ovulation can be estimated.…”

Contraceptive applications of progesterone receptor modulators

“…Mifepristone has the distinct advantage to be highly effective up to 120 hours after unprotected intercourse whereas, with the exception of IUDs, other methods must be applied during the initial 72 hours [11][12][13][14] . Moreover, side effects such as nausea, vomiting, headache, and breast tenderness were significantly less frequent among women given mifepristone than with the other substances [8][9][10] . In one study, 19% of women taking mifepristone complained of excess bleeding as compared to 31% of the women taking LNG 11 .…”

“…Several clinical trials have compared the effectiveness of mifepristone to that of other established methods of EC including danazol, LNG, an intrauterine contraceptive device and the classical Yuzpe method (ethinyl oestradiol 100 mg and LNG 500 mg, repeated after 12 h) [8][9][10][11][12] . Different doses of mifepristone have also been compared 13,14 .…”

Hormonal contraception: recent advances and controversies

“…Mifepristone in a single dose of 600 mg, 100 mg, 50 mg, or 10 mg is equally effective in the prevention of pregnancy and has been shown to be more effective than the combined OC regimen with fewer side effects (33)(34)(35).…”