Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma

Abstract

Background To investigate the expression and biological functions of mitogen‐induced gene 6 (Mig‐6) in esophageal squamous cell carcinoma (ESCC). Methods The expression of Mig‐6 in ESCC tissues and normal esophageal epithelial tissues were measured by immunohistochemistry (IHC) assay. MTT test was applied to detect the proliferative ability of ESCC cells after Mig‐6 was upregulated by transfection. A fluid cytology assay was used to detect apoptosis of ESCC cells. Agilent whole human genome oligo microarray was used to screen different expressed genes and the possible signaling pathways which might be involved. Results The expression of Mig‐6 protein was lower in ESCC tissues compared to normal esophageal epithelial tissues. Mig‐6 could restrain the ESCC cell growth and induce cell apoptosis. PPAR, CAMs and MAPK signaling pathways might be involved. Conclusions Mig‐6 might be a new tumor suppressor gene and a possible target for the specific therapy of ESCC.

ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner

“…ERRFI1 localizes in human chromosome 1p36, a locus that has been widely suggested to harbor putative tumor-suppressor genes (Zhang et al 2007 ). Previous studies have demonstrated that ERRFI1 serves as a tumor suppressor gene with reduced expression in a variety of human cancers, and loss of function of this protein contributes to cancer development (Zhang et al 2007 ; Amatschek et al 2004 ; Cui et al 2022 ). For example, ERRFI1 induces apoptosis of hepatocellular carcinoma cells (Cui et al 2021 ; Qu et al 2022 ).…”