Abstract:The migraine is a neurological disorder that represents a seventh health problem leading cause of years of life lost to disability condition. Lifestyle factors include dieting and fasting, exercising and physical activities, stress level and sleeping and resting habits, smoking and medications and drugs, these factors affecting frequency, duration, and severity of migraine, and changing these factors in lifestyle decreases the frequency and severity of the migraine headache. This study was designed to evaluate the effect of lifestyle modification program on reducing migraine disability among migraineurs suffers. Also, the quasi experimental research design was used in this study. This study was carried out in Ismailia, Egypt. 70 migraineurs suffers were selected from attendance neurology outpatient clinic and emergency department complaining of signs and symptoms of migraines over six months and not complaining of any chronic diseases. Migraineurs suffers who signed the informed consent to participate in this study after explaining the aim of the study. Data collection tools were a demographic questionnaire, migraine headache characteristics, their knowledge about magraine, and their lifestyle habits. Migraine Disability Assessment Test scores was measured in two stages, before and three months after implementation of their lifestyle modification. The frequency, and severity of migraine headache was reducing and migraine disability change from sever disability to mild disability after implementation the program. Consequently, the lifestyle improved the frequency and severity of headaches and self-reported disability from headaches. As well as, the health education to the migraineurs suffers about the prevention of recurrent migraines.