Migraine, Brain Glucose Metabolism and the “Neuroenergetic” Hypothesis: A Scoping Review

Moro, Lorenzo Del; Rota, Eugenia; Pirovano, Elenamaria; Rainero, Innocenzo

doi:10.1016/j.jpain.2022.02.006

Cited by 32 publications

(27 citation statements)

References 240 publications

(321 reference statements)

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“…Arterial hypertension is frequently associated with migraine, and this co-morbidity may be sustained by endothelial dysfunction [ 55 ]. The association of migraine with high blood glucose levels is in agreement with the “neuroenergetic” hypothesis, which suggests impaired brain glucose metabolism [ 56 ]. Obesity plays a role in migraine [ 57 , 58 ].…”

Section: Discussionsupporting

confidence: 71%

Headache in Workers: A Matched Case–Control Study

Prinzio

Arnesano

Meraglia

et al. 2022

EJIHPE

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A case–control study including 446 workers reporting headaches (cases; 136 males and 310 females, mean age 46.71 ± 10.84 years) and 446 age- and sex-matched colleagues without headaches (controls; mean age 45.44 ± 10.13) was conducted in the second half of 2020 in a sample drawn from socio health and commercial services companies to investigate the association of headache with lifestyle, metabolic, and work-related factors. Workers suffering from headache reported higher body weight (OR: 1.92, 95% CI: 1.46–2.53, p < 0.001), higher blood cholesterol (OR: 2.01, 95% CI: 1.46–2.77, p < 0.001), triglyceride (OR: 2.01, 95% CI: 1.20–3.35, p < 0.01), blood glucose (OR: 1.91, 95% CI: 1.16–3.24, p < 0.01), and blood pressure levels (OR: 1.76, 95% CI: 1.23–2.52, p < 0.01). In the year preceding the survey, cases had experienced a higher frequency of workplace violence (OR: 2.29, 95% CI: 1.25–4.20, p < 0.01 for physical aggression, OR: 2.22, 95% CI: 1.45–3.41, p < 0.001 for threat, OR: 2.74, 95% CI: 1.72–4.38, p < 0.001 for harassment) and were more frequently distressed (effort/reward ratio > 1) (OR: 1.82, 95% CI: 1.39–2.40, p < 0.001) than the controls. Compared to the controls, cases also had higher scores on anxiety and depression scales, lower scores on happiness, and lower levels of sleep quality (p < 0.001). The association of headaches with metabolic and mental health problems suggests that monitoring headaches in the workplace could help to identify workers at risk of impairment.

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Section: Discussionsupporting

confidence: 71%

Headache in Workers: A Matched Case–Control Study

Prinzio

Arnesano

Meraglia

et al. 2022

EJIHPE

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“…Some foods might trigger migraine [ 127 ], even if the trigger action of some foods could be a misinterpretation of migraine prodromes [ 128 , 129 ]. More important is the role of diet as a whole in individuals with migraine, given the relevance of glucose metabolism in migraineurs’ brains [ 130 , 131 ]. Diets shifting the brain metabolism to products different from glucose, such as the ketogenic diet, have shown to provide some benefits in migraine management [ 132 , 133 ] decrease of the hypermetabolic feature of migraineurs’ brain.…”

Section: Socio-demographic and Lifestyle Factorsmentioning

confidence: 99%

Applying a biopsychosocial model to migraine: rationale and clinical implications

et al. 2022

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Migraine is a complex condition in which genetic predisposition interacts with other biological and environmental factors determining its course. A hyperresponsive brain cortex, peripheral and central alterations in pain processing, and comorbidities play a role from an individual biological standpoint. Besides, dysfunctional psychological mechanisms, social and lifestyle factors may intervene and impact on the clinical phenotype of the disease, promote its transformation from episodic into chronic migraine and may increase migraine-related disability.Thus, given the multifactorial origin of the condition, the application of a biopsychosocial approach in the management of migraine could favor therapeutic success. While in chronic pain conditions the biopsychosocial approach is already a mainstay of treatment, in migraine the biomedical approach is still dominant. It is instead advisable to carefully consider the individual with migraine as a whole, in order to plan a tailored treatment. In this review, we first reported an analytical and critical discussion of the biological, psychological, and social factors involved in migraine. Then, we addressed the management implications of the application of a biopsychosocial model discussing how the integration between non-pharmacological management and conventional biomedical treatment may provide advantages to migraine care.

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“…The negative correlation between AI values and carotid blood flow may be indicative of the presence of the link between behavior patterns and cerebral blood flow in PS rats. In this case, it is of special importance that the brain is extremely dependent on the delivery of oxygen, glucose, and other substrates from the blood [ 38 ]. Moreover, obtained data also point to the possible link between low GC levels and enhanced cerebral blood flow.…”

Section: Discussionmentioning

confidence: 99%

Paradoxical Anxiety Level Reduction in Animal Chronic Stress: A Unique Role of Hippocampus Neurobiology

Tseĭlikman

Akulov

Shevelev

et al. 2022

IJMS

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A paradoxical reduction in anxiety levels in chronic predator stress paradigm (PS) in Sprague–Dawley rats has recently been shown in previous works. In this paper, we studied the possible neurobiological mechanism of this phenomenon. We segregated PS-exposed Sprague–Dawley rats into the high- and low-anxiety phenotypes. The long-lasting effects of PS on corticosterone levels, blood flow speed in the carotid arteries, diffusion coefficient, and 1H nuclear magnetic resonance spectra in the hippocampus were compared in the high-anxiety and low-anxiety rats. In addition, we evaluated the gene BDNF expression in the hippocampus which is considered to be a main factor of neuroplasticity. We demonstrated that in low-anxiety rats, the corticosterone level was decreased and carotid blood flow speed was increased. Moreover, in the hippocampus of low-anxiety rats compared to the control group and high-anxiety rats, the following changes were observed: (a) a decrease in N-acetyl aspartate levels with a simultaneous increase in phosphoryl ethanol amine levels; (b) an increase in lipid peroxidation levels; (c) a decrease in apparent diffusion coefficient value; (d) an increase in BDNF gene expression. Based on these findings, we proposed that stress-induced anxiety reduction is associated with the elevation of BDNF gene expression directly. Low corticosterone levels and a rise in carotid blood flow speed might facilitate BDNF gene expression. Meanwhile, the decrease in apparent diffusion coefficient value and decrease in N-acetyl aspartate levels, as well as an increase in the lipid peroxidation levels, in the hippocampus possibly reflected destructive changes in the hippocampus. We suggested that in Sprague–Dawley rats, these morphological alterations might be considered as an impetus for further increase in neuroplasticity in the hippocampus.

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Migraine, Brain Glucose Metabolism and the “Neuroenergetic” Hypothesis: A Scoping Review

Cited by 32 publications

References 240 publications

Headache in Workers: A Matched Case–Control Study

Headache in Workers: A Matched Case–Control Study

Applying a biopsychosocial model to migraine: rationale and clinical implications

Paradoxical Anxiety Level Reduction in Animal Chronic Stress: A Unique Role of Hippocampus Neurobiology

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