Migraine: Implication of arachidonic acid metabolites

Efficacy and safety of an olive oil‐based intravenous fat emulsion in adult patients on home parenteral nutrition

“…PGE 2 ) and LTs (from the fourth series, e.g. LTB 4 ) build‐up is initiated in the brain 19 . In vitro and in vivo data suggest that PGs‐like PGE 2 and LTs are involved in neurovascular inflammatory response and may facilitate nociceptor excitation 20 as well as headaches and other symptoms such as nausea and vomiting 19, 21 .…”

“…LTB 4 ) build‐up is initiated in the brain 19 . In vitro and in vivo data suggest that PGs‐like PGE 2 and LTs are involved in neurovascular inflammatory response and may facilitate nociceptor excitation 20 as well as headaches and other symptoms such as nausea and vomiting 19, 21 . This may explain why anti‐inflammatory medications (cyclo‐oxygenase inhibitors) and thromboxane synthase inhibitors shorten the duration and reduce the severity of acute headache attacks.…”

PACAP Induces Light Aversion in Mice by an Inheritable Mechanism Independent of CGRP

“…In general, these genes were over-represented in pathways such as platelet activation, signaling and aggregation (FDR < 0.05), which is consistent with other studies showing PACAP being an inhibitor of platelet activation (Freson et al, 2004;Eneman et al, 2015) (Table 5-6). Other pathways include PI3K-Akt signaling pathway (FDR <0.05) and arachidonic acid metabolism (FDR < 0.05), which have been suggested to be involved in migraine (Puig-Parellada et al, 1993;Liu et al, 2017). Gene ontology revealed a number of biological functions involved in bone mineralization and ossification (Table 5-7).…”

Leukotrienes: Biosynthesis, Metabolism, and Pathophysiologic Significance

“…Lipoxygenase products were implicated in the early encephalitic phase of MS. LTB, and LTC, stimulate the adherence of leukocytes in MS patients treated with high doses of prednisone, possibly reflecting alterations of membrane processes in MS leukocytes associated with calcium homeostasis and the arachidonic acid metabolic cascade (123). Finally, LT might participate in the cerebrovascular reactions in migraine (124,125).…”