Migraine Is Associated With Livedo Reticularis: A Prospective Study

Abstract

In women, migraine is associated with stroke, coronary artery disease, deep venous thrombosis, as well as livedo reticularis, a dermatopathy which has been pathologically linked to cerebral vasculopathy. Whether migraineurs with livedo reticularis compose a subset at higher risk of thrombosis, including stroke, deserves further investigation.

Livedo reticularis: An update

“…LR may be more commonly present in patients with migraine than in the general population. 26 A chart review of patients with migraine headaches demonstrated that patients with both migraines and LR were more likely to have had a stroke. 23 These results suggest that LR can be used as a marker for patients with migraine who may be at risk of future strokes and, thus, development of Sneddon's syndrome.…”

The spectrum of differential diagnosis in neurological patients with livedo reticularis and livedo racemosa

“…Sneddon's syndrome is characterised by the association of cerebrovascular events with widespread livedo racemosa [96].SS was first described by Champion and Rook in 1960 [20] and was named after the British dermatologist I. B. Sneddon who reported the combination of livedo racemosa with symptoms of cerebrovascular defect in six patients in 1965 [92].…”

“…In 1946 Divry and van Bogaert described three brothers with livedo racemosa,seizures,pseudobulbar syndrome, extrapyramidal and pyramidal signs and dementia [96]. Since then more cases have been reported.…”

“…Historically the distinguishing features between Divry-van Bogaert syndrome and SS have been the presence of cerebromeningeal angiomatosis and the familiar presentation of Divry-van Bogaert syndrome [94,96], although there have also been several reports of vascular dilatation with leptomeningeal and transdural anastomoses in SS [2].Adding to the confusion, an autosomal dominant and recessive inheritance in SS has been reported [94].…”

Circulating microparticles in migraine with aura: Cause or consequence, a link to stroke

“…The discovery of migraine's association with a number of other vascular conditions such as Raynaud's phenomenon (3), variant angina (4), pre-eclampsia (5), and livedo reticularis (6), has fueled speculation for a pivotal role of the endothelium in migraine pathogenesis and in migraineassociated stroke (7).…”