Migraine without Aura -Towards a New Definition

Francis, M V

doi:10.4172/2472-1913.100008

Cited by 2 publications

(1 citation statement)

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“…According to a survey, the 1-year prevalence of migraine in Pakistan is 22.7% being more common in the age group of 40–49 years ( Ashina et al, 2021 ). Despite the substantial burden posed by this disorder, it is underdiagnosed in the majority of the population ( Francis, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

PRDM16, LRP1 and TRPM8 genetic polymorphisms are risk factor for Pakistani migraine patients

Zafar

Saleem

Sheikh

et al. 2021

Saudi Journal of Biological Sciences

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Background Migraine is a chronic neurovascular condition characterized by recurring attacks of pulsating headaches. Genome-wide association studies (GWAS) identified many potential loci associated with migraine. To check the association of polymorphisms of PRDM16 (rs2651899), LRP1 (rs11172113), and TRPM8 (rs10166942) with migraine, the first time a case-control study was conducted in understudied Pakistani population. Methods The study included 127 migraine patients (21 in migraine with aura and 106 with migraine without aura group) and 120 healthy control subjects from different areas of Punjab, Pakistan. Blood samples were collected from all the participants, and DNA was isolated from the lymphocytes by the modified organic method. Sanger’s sequencing was done for PRDM16 ( rs2651899), LRP1 (rs11172113), and TRPM8 (rs10166942) in all the samples to check the genotype. Logistic regression analysis was done using SPSS 20.0 to check the association of these SNPs with migraine susceptibility. Results We found statistically significant differences between case and control group for PRDM16 ( rs2651899) at genotypic level (p < 0.001), allelic level (p < 0.001; OR 3.088; 95% CI 2.082–4.579) and for dominant model (p < 0.001; OR 5.437; 95% CI 3.112–9.498). The major findings of this study suggested that PRDM16 rs2651899 is strongly associated with migraine in overall and subgroup analysis of genotypes. LRP1 (rs11172113) showed significant association with migraine except in subgroup comparison. A similar trend of association was found for TRPM8 (rs10166942) however, significant association was found only at the allelic level but no significant difference was seen at the genotypic level between case and control. One novel mutation c.67 + 4436_67 + 4438delA was also identified in the current study near LRP1 (rs11172113) polymorphic site. Conclusion In this first-ever replication report from Pakistan, PRDM16 ( rs2651899) was found as a potential genetic marker in migraine susceptibility while LRP1 (rs11172113) and TRPM8 (rs10166942) showed partial association in subgroup analysis.

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Section: Introductionmentioning

confidence: 99%