Migrasome biogenesis and functions

Yu, Shunbang; Yu, Li

doi:10.1111/febs.16183

Cited by 67 publications

(58 citation statements)

References 18 publications

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“…The transporting mechanisms of damaged mitochondria to migrasomes are relatively clear [ 6 ]. Nevertheless, the origin of small vesicles inside migrasomes and the sorting and transporting mechanisms of these small vesicles, nucleic acids, and proteins into migrasomes remain to be identified [ 1 , 4 , 67 , 109 ].…”

Section: Discussionmentioning

confidence: 99%

“…Jiao et al found that migrasomes were extensively generated by circulating neutrophils in mice, as that around 87% of migrasomes from blood originated from neutrophils [ 6 ]. Some neutrophil-derived migrasomes can adhere to vessels in the circulation for a long time, while some are detached quickly after generation [ 66 , 67 ]. Most importantly, the migrasomes generated by neutrophils contain damaged mitochondria [ 6 ].…”

Section: The Current Understanding Of the Biological Functions Of Mig...mentioning

confidence: 99%

“…When injecting TSPAN9 −/− or WT bone marrow neutrophils to WT mice, WT neutrophils significantly outnumber TSPAN9 −/− neutrophils after one day's circulation; thus, mitocytosis physiologically contributes to the viability of neutrophils in the circulation [ 6 ]. Therefore, disposal of damaged mitochondria via releasing migrasomes is essential for keeping circulating neutrophils alive; however, these are limited to the mice in the steady state [ 6 , 67 ], and using the infectious animal models or patients to explore the functions of migrasomes in other migratory immune cell development and in antiviral innate immunity will be more excited.…”

Section: The Current Understanding Of the Biological Functions Of Mig...mentioning

confidence: 99%

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Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases

Zhang

Guo

et al. 2022

Oxidative Medicine and Cellular Longevity

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Migrasomes are migration-dependent membrane-bound vesicular structures that contain cellular contents and small vesicles. Migrasomes grow on the tips or intersections of the retraction fibers after cells migrate away. The process of releasing migrasomes into the extracellular space is named as “migracytosis”. After releasing, they can be taken up by the surrounding cells, or rupture and further release their contents into the extracellular environment. Physiologically, migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation and discard the damaged mitochondria in response to mild mitochondrial stresses. Pathologically, migrasomes are released from podocyte during early podocyte stress and/or damage, from platelets after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from microglia/macrophages of the ischemic brain, and from tumor necrosis factor α (TNFα)-activated endothelial cells (ECs); thus, this newly discovered extracellular vesicle is involved in all these pathological processes. Moreover, migrasomes can modulate the proliferation of cancer cell via lateral transferring mRNA and protein. In this review, we will summarize the biogenesis, release, uptake, and rupture of migrasomes and discuss its biological roles in development, redox signalling, innate immunity and COVID-19, cardio-cerebrovascular diseases, renal diseases, and cancer biology, all of these highlight the importance of migrasomes in modulating body homeostasis and diseases.

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Section: Discussionmentioning

confidence: 99%

Section: The Current Understanding Of the Biological Functions Of Mig...mentioning

confidence: 99%

Section: The Current Understanding Of the Biological Functions Of Mig...mentioning

confidence: 99%

See 1 more Smart Citation

Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases

Zhang

Guo

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Migrasomes are short-lived structures that rupture soon after their formation and release their content of signaling molecules to orientate the migration of following cells (Jiang et al, 2019). Migrasomes can also be internalized by surrounding cells and thereby transfer regulatory factors they contain to modulate recipient cells fate (Jiang et al, 2019; Yu & Yu, 2021). While it is proven that fibroblasts can produce migrasomes, it is not clear whether these structures may participate in orienting cancer cell migration.…”

Section: Main Textmentioning

confidence: 99%

Fibroblasts generate topographical cues that steer cancer cell migration

Baschieri

Illand

Barbazán

et al. 2022

Preprint

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Fibroblasts play a fundamental role in tumor development. Among other functions, they regulate cancer cells migration through rearranging the extracellular matrix, secreting soluble factors and establishing direct physical contacts with cancer cells. Here, we report that migrating fibroblasts deposit on the substrate a network of tubular structures that serves as guidance cue for cancer cell migration. Such membranous tubular network, hereafter called tracks, is stably anchored to the substrate in a β5 integrin-dependent manner. We found that cancer cells specifically adhere to tracks by using clathrin-coated structures that pinch and engulf tracks. Tracks represent thus a spatial memory of fibroblast migration paths that is read and erased by cancer cells directionally migrating along them. We propose that fibroblast tracks represent a topography-based intercellular communication system capable of steering cancer cells migration.

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“…Thus, while it is technically possible to isolate migrasomes from developmental organisms, there is room for improvement. Future studies will also need to establish quality controls to ensure migrasomes specifically are being enriched for further study [ 22 ].…”

Section: Analyzing Extracellular Vesicles and Protrusions In Developmentmentioning

confidence: 99%

Extracellular Vesicles and Membrane Protrusions in Developmental Signaling

Gustafson

Gammill

2022

JDB

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During embryonic development, cells communicate with each other to determine cell fate, guide migration, and shape morphogenesis. While the relevant secreted factors and their downstream target genes have been characterized extensively, how these signals travel between embryonic cells is still emerging. Evidence is accumulating that extracellular vesicles (EVs), which are well defined in cell culture and cancer, offer a crucial means of communication in embryos. Moreover, the release and/or reception of EVs is often facilitated by fine cellular protrusions, which have a history of study in development. However, due in part to the complexities of identifying fragile nanometer-scale extracellular structures within the three-dimensional embryonic environment, the nomenclature of developmental EVs and protrusions can be ambiguous, confounding progress. In this review, we provide a robust guide to categorizing these structures in order to enable comparisons between developmental systems and stages. Then, we discuss existing evidence supporting a role for EVs and fine cellular protrusions throughout development.

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Migrasome biogenesis and functions

Cited by 67 publications

References 18 publications

Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases

Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases

Fibroblasts generate topographical cues that steer cancer cell migration

Extracellular Vesicles and Membrane Protrusions in Developmental Signaling

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