Mild Asthma and Chronic Bronchitis Seem to Influence Functional Exercise Capacity: A Multi-Case Control Study

Marcon, Alessandro; Girardi, Paolo; Ferrari, Marcello; Olivieri, Mario; Accordini, Simone; Bombieri, Cristina; Bortolami, Oscar; Braggion, Marco; Cappa, Veronica; Cazzoletti, Lucia; Locatelli, Francesca; Nicolis, Morena; Perbellini, Luigi; Verlato, Giuseppe; Zanolin, Maria Elisabetta; Marco, Roberto de

doi:10.1159/000345137

Cited by 19 publications

(17 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subjects with a FEV 1 /FVC <70% or <LLN underwent the bronchodilator challenge test and were invited (if eligible) to undergo the methacholine challenge test. Skin prick tests to 14 common allergens were carried out as described elsewhere , and atopy was defined as having a >3 mm reaction.…”

Section: Methodsmentioning

confidence: 99%

Dietary fats, olive oil and respiratory diseases in Italian adults: A population‐based study

Cazzoletti

Zanolin

Spelta

et al. 2019

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

Background: Fat intake has been associated with respiratory diseases, with conflicting results.Objective: We studied the association between asthma and rhinitis with dietary fats, and their food sources in an Italian population.Methods: Clinical and nutritional information was collected for 871 subjects (aged 20-84) from the population-based multi-case-control study Genes Environment Interaction in Respiratory Diseases (GEIRD): 145 with current asthma (CA), 77 with past asthma (PA), 305 with rhinitis and 344 controls. Food intake was collected using the EPIC (European Investigation into Cancer and Nutrition) Food Frequency Questionnaire. The associations between fats and respiratory diseases were estimated by multinomial models. Fats and their dietary sources were analysed both as continuous variables and as quartiles. Results: Monounsaturated fatty acids and oleic acid were associated with a reduced risk of CA in both continuous (RRR = 0.68, 95%CI: 0.48; 0.96; RRR = 0.69; 95%CI: 0.49; 0.97, per 10 g, respectively) and per-quartile analyses (p for trend = 0.028 and 0.024, respectively). Olive oil was associated with a decreased risk of CA (RRR = 0.80; 95%CI: 0.65; 0.98 per 10 g). An increased risk of rhinitis was associated with moderate total fat and SFA intake.Conclusions: High dietary intakes of oleic acid and of olive oil are associated with a lower risk of asthma but not of rhinitis.

show abstract

Section: Methodsmentioning

confidence: 99%

Dietary fats, olive oil and respiratory diseases in Italian adults: A population‐based study

Cazzoletti

Zanolin

Spelta

et al. 2019

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

“…Comparing mild asthma patients and healthy subjects, Marcon et al found that the former had a shorter walking distance although not reaching the minimal clinical important difference value (À17.1 m, p ¼ 0.02) [80]. Not surprisingly, a more significant difference is seen with difficult-to-treat and severe asthma patients [75], in particular if patients are treated with oral corticosteroids [32].…”

Section: Walking Testsmentioning

confidence: 99%

Activity limitation and exertional dyspnea in adult asthmatic patients: What do we know?

Vermeulen

Garcia

Ninane

et al. 2016

Respiratory Medicine

View full text Add to dashboard Cite

Limitation of activity is the most cited symptom described by uncontrolled asthma patients. Assessment of activity limitation can be undertaken through several ways, more or less complex, subjective or objective. Yet little is known about the link between patients sensations and objective measurements. The present review reports the current knowledge regarding activity limitation and symptom perception (i.e., exertional dyspnea) in adult patients with asthma. This work is based on references indexed by PubMed, irrespective of the year of publication. Overall, patients with stable asthma do not have a more sedentary lifestyle than healthy subjects. However, during a cycle ergometric test, the maximal load is reduced when FEV1, FVC and muscle strengths are decreased. Additionally, during the six-minute walking test, mild asthma patients walk less than healthy subjects even if the minimal clinically important difference is not reached. The major complaint of asthma patients when exercising is dyspnea that is mainly related to the inspiratory effort and also to dynamic hyperinflation in some circumstances. Finally, the administration of bronchodilator does not improve the ventilatory pattern and the exercise capacity of asthma patients and little is known on its effect on exertional dyspnea. The present review allows to conclude that until now there is no gold standard test allowing the objective assessment of "activity limitation and exertional dyspnea" in asthma patients.

show abstract

“…One estimated minimal clinical difference for the 6MWT distance corresponds to 26 m [ 34 ]. In absence of sarcoidosis-specific references, we suggest according to Marcon [ 35 ], a 6MWT distance of approximately 600 m (SD 80). Assuming a 2-sided type I error of 2.5% and a power of 90%, the overall sample size on the basis of a paired t test is 121.…”

Section: Methodsmentioning

confidence: 99%

ProKaSaRe Study Protocol: A Prospective Multicenter Study of Pulmonary Rehabilitation of Patients With Sarcoidosis

Lingner

Großhennig²,

Flunkert³

et al. 2015

JMIR Res Protoc

View full text Add to dashboard Cite

BackgroundAvailable data assessing the efficacy of pulmonary rehabilitation for patients with chronic sarcoidosis are scant; for Germany, there are none at all.ObjectiveTo gain information about the benefit of in-house pulmonary rehabilitation for patients with chronic sarcoidosis and for the health care system, we intend to collect data in a prospective multicenter “real-life” cohort trial.MethodsProKaSaRe (Prospektive Katamnesestudie Sarkoidose in der pneumologischen Rehabilitation) [Prospective Catamnesis Study of Sarcoidosis in Pulmonary Rehabilitation] will assess a multimodal 3-week inpatient pulmonary rehabilitation program for adult patients with chronic sarcoidosis over a 1-year follow-up time. Defined specific clinical measurements and tests will be performed at the beginning and the end of the rehabilitation. In addition, questionnaires concerning health-related quality of life and the patients’ symptoms will be provided to all patients. Inclusion criteria will be referral to one of the 6 participating pulmonary rehabilitation clinics in Germany for sarcoidosis and age between 18 and 80 years. Patients will only be excluded for a lack of German language skills or the inability to understand and complete the study questionnaires. To rule out seasonal influences, the recruitment will take place over a period of 1 year. In total, at least 121 patients are planned to be included. A descriptive statistical analysis of the data will be performed, including multivariate analyses. The primary outcomes are specific health-related quality of life (St George’s Respiratory Questionnaire) and exercise capacity (6-minute walk test). The secondary outcomes are several routine lung function and laboratory parameters, dyspnea scores and blood gas analysis at rest and during exercise, changes in fatigue, psychological burden, and generic health-related quality of life (36-item Short Form Health Survey).ResultsFunding was obtained on October 12, 2010; enrollment began on January 15, 2011 and was completed by January 14, 2012. Results are anticipated late summer 2015.ConclusionsDue to the large number of participants, we expect to obtain representative findings concerning the effectiveness of pulmonary rehabilitation for patients with sarcoidosis and to provide a dataset of assessed objective and subjective short- and long-term changes due to pulmonary rehabilitation. The results should form the basis for the planning of a randomized controlled trial.Trial RegistrationGerman Clinical Trials Register: DRKS00000560; https://drks-neu.uniklinik-freiburg.de/ drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00000560 (Archived by WebCite® at http://www.webcitation.org/6dKb5X87R)

show abstract

Mild Asthma and Chronic Bronchitis Seem to Influence Functional Exercise Capacity: A Multi-Case Control Study

Cited by 19 publications

References 66 publications

Dietary fats, olive oil and respiratory diseases in Italian adults: A population‐based study

Dietary fats, olive oil and respiratory diseases in Italian adults: A population‐based study

Activity limitation and exertional dyspnea in adult asthmatic patients: What do we know?

ProKaSaRe Study Protocol: A Prospective Multicenter Study of Pulmonary Rehabilitation of Patients With Sarcoidosis

Contact Info

Product

Resources

About