Mild hypothermia induced by a helmet device: a clinical feasibility study

Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest

“…2,3 Therapeutic hypothermia (TH) has been shown to improve both survival and neurological outcomes after cardiac arrest in several clinical trials, and has been endorsed as an evidencebased treatment modality by the International Liaison Committee on Resuscitation. [4][5][6][7] Currently TH is applied in the post-resuscitation time period, to minimize reperfusion injury following ischemia and improve neurological outcome after ROSC is achieved. 8 Earlier animal work by our group and others has suggested that intra-arrest hypothermia may provide additional survival benefit compared to TH after resuscitation.…”

Therapeutic Hypothermia for Acute Neurological Injuries

“…In a small randomized placebo-controlled trial of 30 patients, induced hypothermia demonstrated a beneficial effect in non-shockable rhythm patients [96], whereas in a more recent trial, induced hypothermia was related to a trend toward a harmful effect [81]. In observational studies, mixed results were also reported [4].…”

“…Similar to the cool cap in infants, local cerebral cooling using a cooling helmet, sometimes in combination with neck cooling, has been tried in the adult [96][97][98][99]. However, due to a smaller head-tobody ratio in adults compared to infants, cooling helmets are less commonly used in adults, as the induction rate is slow and maintaining target temperature is difficult [100].…”

Erweiterte Reanimationsmaßnahmen für Erwachsene („advanced life support“)

“…In den ersten 48 h nach Kreislaufstillstand ist eine hypertherme Phase typisch (Hyperpyrexie; [696,697,698] [709]. Sechs Studien mit historischen Kontrollgruppen wiesen den Nutzen der therapeutischen Hypothermie bei komatösen Überlebenden eines präklinischen Kreislaufstillstands aufgrund aller EKG-Rhythmen nach [630,633,710,711,712,713].…”