Mild ventriculomegaly in the fetus, natural history, associated findings and outcome of isolated mild ventriculomegaly: a literature review

Kelly, Edmond; Allen, Victoria M.; Seaward, Gareth; Windrim, Rory; Ryan, Greg

doi:10.1002/pd.138

Cited by 110 publications

(95 citation statements)

References 21 publications

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“…It is interesting that the odds increased over the years: 1 : 18 and 1 : 30 in the periods 1985-1988 and 1989-1992 respectively and 1 : 3 in the periods 1993-1996 and 1997-2000. Although there are no available data on diagnostic accuracy for borderline VM as opposed to severe VM, we speculate that overdiagnosis may in part be related to the publication of studies emphasizing the association of borderline VM with other CNS and non-CNS malformations or chromosomal abnormalities (Goldstein et al, 1990;Bromley et al, 1991;Patel et al, 1994;Bloom et al, 1997;Tomlinson et al, 1997;Vergani et al, 1998;Pilu et al, 1999;Graham et al, 2001;Greco et al, 2001;Kelly et al, 2001;Mercier et al, 2001). This might have induced overestimation of the ventricular width measurement to avoid missing associated anomalies.…”

Section: Investigation and Findingsmentioning

confidence: 86%

The significance of fetal ventriculomegaly: etiology, short‐ and long‐term outcomes

Gaglioti¹,

Oberto²,

Todros³

2009

Prenatal Diagnosis

138

119

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Fetal cerebral ventriculomegaly (VM) is diagnosed when the width of one or both ventricles, measured at the level of the glomus of the choroid plexus (atrium), is ≥10 mm. VM can result from different processes: abnormal turnover of the cerebrospinal fluid (CSF), neuronal migration disorders, and destructive processes. In a high percentage of cases, it is associated with structural malformations of the central nervous system (CNS), but also of other organs and systems. The rate of associated malformations is higher (≥60%) in severe VM (>15 mm) and lower (10-50%) in cases of borderline VM (10-15 mm). When malformations are not present, aneuploidies are found in 3-15% of borderline VM; the percentage is lower in severe VM. The neurodevelopmental outcome of isolated VM is normal in >90% of cases if the measurement of ventricular width is between 10 and 12 mm; it is less favorable when the measurement is >12 mm.

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Section: Investigation and Findingsmentioning

confidence: 86%

The significance of fetal ventriculomegaly: etiology, short‐ and long‐term outcomes

Gaglioti¹,

Oberto²,

Todros³

2009

Prenatal Diagnosis

138

119

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“…3 The risk of chromosomal abnormalities associated with isolated ventriculomegaly is reported to be 4%. 5 Significant chromosomal anomalies (3.5%) are reported in association with echogenic bowel in a large French collaborative study. 10 Likelihood ratios reported for aneuploidy in echogenic bowel vary from 3 to 6.7.…”

Section: Counselingmentioning

confidence: 96%

Uptake of invasive prenatal diagnostic tests in women after detection of soft markers for chromosomal abnormality on ultrasonographic evaluation

Sharda

Phadke

2007

J Perinatol

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Objective: Use of soft ultrasonographic markers during routine prenatal ultrasonography (USG) may be used for the screening of aneuploidy in the low-risk population. The aim of this study was to evaluate the acceptance of an invasive test for prenatal diagnosis and to assess the role of various factors in the decision-making regarding an invasive test when confronted with risk for aneuploidy after a soft marker is detected on routine antenatal ultrasonogram.Study design: Women were referred for USG in our department by primary obstetricians for indications such as a previous child with a congenital malformation, genetic disorder, stillbirth or in women with recurrent spontaneous abortions. Some of the women were referred after prenatal detection of a soft marker on USG. They were screened for soft markers associated with chromosomal abnormality. They were counseled regarding the age-specific risk and the risk of aneuploidy after detection of a marker in comparison to the general population's risk of Down's syndrome. They were also counseled regarding the risk of a procedurerelated abortion (0.5%) following an invasive procedure before their decision regarding the use of amniocentesis was made.Result: Twenty women out of 50 (40%) opted for amniocentesis. Except in one case of trisomy 21 in a fetus with short femur and humerus, all others had normal karyotype. The uptake of the test was comparable between primigravida (33%), women with poor obstetric history (46%) and women with at least one normal live child (45%). There was no statistical difference in the uptake of invasive test based on gestational age as well. Uptake of amniocentesis was higher (78%) in cases with nuchal thickening as compared to other markers (35%).Conclusion: Ultrasonographic detection of soft markers is associated with a high frequency of uptake for invasive prenatal testing. Increased nuchal thickening is associated with a higher acceptance of amniocentesis. Maternal age, gestational age or previous obstetric history were not associated with the decision to undergo amniocentesis.

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“…While prenatal ultrasonography remains the main technique for screening intracranial abnormalities in utero, fetal MRI plays a key role in the exact evaluation of the complex fetal brain anatomy [8][9][10] . Ventriculomegaly is one of the most frequent indications for fetal MRI 11 and occurs in about 1% of all pregnancies 12 . It is defined as the atrium of the lateral ventricle being wider than 10 mm on coronal imaging 13 .…”

Section: Case Reportmentioning

confidence: 99%

Serial Fetal MRI for the Diagnosis of Aicardi Syndrome

et al. 2013

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Mild ventriculomegaly in the fetus, natural history, associated findings and outcome of isolated mild ventriculomegaly: a literature review

Cited by 110 publications

References 21 publications

The significance of fetal ventriculomegaly: etiology, short‐ and long‐term outcomes

The significance of fetal ventriculomegaly: etiology, short‐ and long‐term outcomes

Uptake of invasive prenatal diagnostic tests in women after detection of soft markers for chromosomal abnormality on ultrasonographic evaluation

Serial Fetal MRI for the Diagnosis of Aicardi Syndrome

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