Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice

Abstract

Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.

Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice

“…Accumulating evidence has shown that REV-ERBs negatively regulate the expression of various proinflammatory molecules such as the cytokine interleukin-6 (IL-6) and the chemokine CCL2, following binding of the synthetic REV-ERB-specific agonists GSK4112 and SR9009 in macrophages (Sato et al, 2014;. A previous finding showed mildly increased mechanical nociceptive sensitivity in REV-ERBα knockout mice (Lee et al, 2016). Furthermore, it is possible that REV-ERBs might be a new target as analgesic for osteoarthritisinduced pain (Das et al, 2018).…”