Miliary tuberculosis characterised by lipomembranous fat necrosis

Yeh, Lisa J; Shively, Nathan R; Isacke, Ross N; Dowling, Christopher A; Stogsdill, Patricia

doi:10.1016/s1473-3099(15)00437-5

Cited by 5 publications

(2 citation statements)

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“…Subcutaneous LFN has been reported in venous insufficiency diseases (including hypodermatitis sclerodermiformis, stasis dermatitis, deep venous thrombosis, thrombophlebitis, varicose veins, and lipodermatosclerosis) ( 11 , 14-16 , 19 , 30-32 , 34 , 35 , 48 ), erythema nodosum ( 9 , 11 , 14 , 35 ), erythema induratum ( 11 , 35 ), traumatic panniculitis ( 11 , 35 ), pancreatic panniculitis ( 11 , 35 ), necrobiosis lipoidica ( 9 , 11 , 35 ), nodular cystic fat necrosis ( 8 , 18 ), sclerosing lipogranuloma ( 35 ), morphea or scleroderma ( 9 , 11 , 18 , 35 ), lupus panniculitis or discoid lupus erythematosus ( 9 , 11 , 17 , 20 , 21 , 33 , 35 ), Behçet disease ( 11 ), Sjögren syndrome ( 18 ), mixed connective tissue disease ( 12 ), polyarteritis nodosa or vasculitis ( 9 , 11 , 35 ), lichen amyloidosis ( 47 ), erysipelas ( 9 ), atypical mycobacteria or miliary tuberculosis ( 11 , 13 , 35 ), diabetes mellitus ( 11 , 16 , 35 ...…”

Section: Lfn In Various Locations and Diseasesmentioning

confidence: 99%

“…Such necrotic fat cells or lipogranulomatous lesions can be resolved during the relatively early stages of the disease. However, another unique form of white fat necrosis, designated lipomembranous fat necrosis (LFN) (7)(8)(9)(10)(11)(12)(13)(14)(15), also called lipomembranous changes (8,(15)(16)(17)(18)(19)(20)(21), membranous fat necrosis (1,15,(22)(23)(24)(25)(26)(27)(28)(29), membranocystic changes or fat necrosis (7,8,11,(14)(15)(16)(17)(28)(29)(30)(31)(32)(33)(34), membranous lipodystrophy-like changes (30,31), and pseudomembranous fat necrosis (7,35), is found in fibrotic tissues or later stages of various diseases (9,12,…”

Section: Introductionmentioning

confidence: 99%

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Lipomembranous fat necrosis: A distinctive and unique morphology (Review)

et al. 2022

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Lipomembranous fat necrosis (LFN) is an uncommon but distinct form of fat necrosis, which is characterized by eosinophilic, crenulated and/or serpiginous membranes. LFN exhibits macrocystic, microcystic and/or crushed features. LFN is routinely detectable on hematoxylin and eosin (H&E)-stained sections, and is present both in the acute phase and in the later or fibrous stage of necrotic fatty lesions. Smaller crushed LFN embedded within fibrous tissues may be difficult to recognize on H&E-stained sections, but can be highlighted by some staining techniques, including Masson trichrome, periodic acid-Schiff, orcein, long Ziehl-Neelsen stain, silver impregnation, phosphotungstic acid-hematoxylin and luxol fast blue staining. LFN was initially considered a specific feature of Nasu-Hakola disease, but has since been identified in various subcutaneous or intraabdominal lesions related to ischemic conditions or venous insufficiency. In addition, LFN is detectable in intra-articular loose bodies and aortic valves with or without dysfunction, suggesting that LFN is also associated with ischemia-like hypoxic conditions or malnutrition. LFN is considered to be a histological hallmark of hidden ischemic or hypoxic/malnourished conditions in various diseases; however, the exact mechanisms of LFN remain poorly understood. The present review described the clinicopathological features of this interesting, but poorly characterized, condition.

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