Milk growth factor (MGF) induces transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms

Growth-active peptides are produced from α-lactalbumin and lysozyme

“…Only recent studies reported that LA and HAMLET (LA is bound with oleic acid) induced apoptosis in tumor cells (Svanborg et al, 2003;Fischer et al, 2004;Baltzer et al, 2004;Xu et al, 2005). All of these reports suggested some relevance to our recent finding that MGF has differentiation activity (Kanda et al, 2005;Kanda et al, 2006).…”

“…In addition to the growth activity, we recently reported that MGF possessed differential activities. One is that MGF induced differentiation of NT2/D1 cells, human embryonal cells that have possibility to progress to the neural side (Kanda et al, 2005) and other is that MGF induced transformation into ATDC5 cells, prechondrocytes, and cooperates with retinoic acid to transform the cells into new forms (Kanda et al, 2006). These make considerable and important contributions to the growth of embryos and infants.…”