Milk oligosaccharides: Structural and technological aspects

Mehra, Rekha; Kelly, Phil

doi:10.1016/j.idairyj.2006.06.008

Cited by 77 publications

(48 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For a recent review of milk oligosaccharides, see Mehra and Kelly (2006). Several methods for structural determination of human milk oligosaccharides have been compared by Ninonuevo et al (2006).…”

Section: Milk Oligosaccharidesmentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for the period 2005–2006

Harvey

2010

Mass Spectrometry Reviews

View full text Add to dashboard Cite

This review is the fourth update of the original review, published in 1999, on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2006. The review covers fundamental studies, fragmentation of carbohydrate ions, method developments, and applications of the technique to the analysis of different types of carbohydrate. Specific compound classes that are covered include carbohydrate polymers from plants, N- and O-linked glycans from glycoproteins, glycated proteins, glycolipids from bacteria, glycosides, and various other natural products. There is a short section on the use of MALDI-TOF mass spectrometry for the study of enzymes involved in glycan processing, a section on industrial processes, particularly the development of biopharmaceuticals and a section on the use of MALDI-MS to monitor products of chemical synthesis of carbohydrates. Large carbohydrate-protein complexes and glycodendrimers are highlighted in this final section.

show abstract

Section: Milk Oligosaccharidesmentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for the period 2005–2006

Harvey

2010

Mass Spectrometry Reviews

View full text Add to dashboard Cite

show abstract

“…The milk oligosaccharide content of goat milk is 0.25~0.39 g/l; this is higher than that of bovine (0.03~0.06 g/l) or ovine (0.02~0.04 g/l) milk. In addition, the variety of oligosaccharides in goat milk is greater than that in bovine or ovine milk, as shown by the profi les from HPEAC analysis Mehra & Kelly, 2006). Colostrum from the Japanese Saanen breed contains more 6'-SL than 3'-SL; it also contains 6'-N-glycolylneuraminyllactose (Neu5Gc(α2-6)Gal(β1-4)Glc), Gal(α1-3)Gal(β1-4)Glc, Gal(β1-3)Gal(β1-4)Glc, Gal(β1-6)Gal(β1-4)Glc and 2'-FL (Urashima et al, 1994(Urashima et al, , 1997.…”

Section: Milk Oligosaccharides Of the Cow And Other Domestic Farm Animentioning

confidence: 99%

Oligosaccharides in Milk: Their Benefits and Future Utilization

Urashima¹,

Taufik²

2010

medpet

View full text Add to dashboard Cite

The percentage of carbohydrate in the milk/colostrum of the mammalian is range from trace to over 10%, of which disaccharide lactose (Gal(β1-4)Glc) is usually constitutes the major part. Apart from the lactose (Gal(β1-4)Glc; Gal, D-galactose; Glc, D-glucose), the rest of carbohydrate components is composed of variety of sugars, commonly named as milk oligosaccharides. Human mature milk and colostrum contain 12 ~ 13 g/l and 22 ~ 24 g/l of oligosaccharides, respectively. In contrast, bovine colostrum contains more than 1 g/l oligosaccharides and this concentration rapidly decreases after 48 hr post partum. Most of human milk oligosaccharides (HMO) are resistant to digestion and absorption within the small intestine. Therefore they can reach the infant colon, where they can act as prebiotics that stimulate the growth of benefi cial microorganisms such as various species of Bifi dobacterium. They can also act as receptor analogues that inhibit the a achment of pathogenic microorganisms to the infant's colonic mucosa. A small part of the milk oligosaccharides is absorbed intact into the circulation and it has been hypothesized that these may act as immunomodulators. Generally, the bovine milk oligosaccharides are believed not to be absorbed by human adults or infants, thus making them available to be utilized as prebiotics or anti-infection materials. The colostrum of cows and other domestic farm animals is a potential source of free oligosaccharides, and oligosaccharides isolated from these natural sources can be utilized as functional foods or animal feedstuff s on the industrial scale.Key words: milk, oligosaccharides, prebiotic, Bifi dobacterium * Corresponding author: e-mail: urashima@obihiro.ac.jp oligosaccharides . In this review, we will introduce the structural feature of human milk oligosaccharides, on their fate within the gastrointestinal tract as well as on their possible biological functions as prebiotics, anti infection agents and immunomodulation factors. In addition, we will discuss the possibility of the commercial utilization of bovine milk oligosaccharides and those of other domestic farm animals. THE CHEMICAL STRUCTURES AND THEIR QUANTITATIVE ASPECTS OF HUMAN MILK OLIGOSACCHARIDESThe structures of at least 115 human milk oligosaccharides (HMOs) have been determined to date (Urashima et al., in press), while as many as 200 diff erent oligosaccharides have been separated and studied by microfl uidic high performance liquid chromatography

show abstract

“…These sugars make a substantial contribution to the carbohydrate content, in human milk for example up to 1.4 % of the entire carbohydrate content (Korhonen & Pihlanto, 2007). Oligosaccharides contain between 3 -10 monosaccharide units that are linked through glycosidic bonds (Mehra & Kelly, 2006). Great deals of previous research on oligosaccharides are mostly focused on human milk since they are highly abundant in human milk.…”

Section: Oligosaccharidesmentioning

confidence: 99%

Bioactive Components in Milk and Dairy Products

Park¹

2009

131

View full text Add to dashboard Cite

Milk oligosaccharides: Structural and technological aspects

Cited by 77 publications

References 30 publications

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for the period 2005–2006

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for the period 2005–2006

Oligosaccharides in Milk: Their Benefits and Future Utilization

Bioactive Components in Milk and Dairy Products

Contact Info

Product

Resources

About