Psychedelics are a class of substances that induce profound alterations in perception, cognition, and consciousness. They include substances such as psilocybin (found in certain mushrooms), LSD, and DMT. Drug tourism, on the other hand, refers to the practice of traveling to destinations specifically to engage in the consumption or exploration of drugs, both legal and illegal. It encompasses a range of experiences, from seeking out prescription medications at lower costs to participating in psychedelic retreats or engaging in recreational drug use. Drug tourism, encompassing legal and illegal drugs, is a significant part of the tourism industry, generating substantial revenue and attracting tourists to various destinations. This chapter delves into the fascinating and complex world of drugs and psychedelics in tourism, examining the resurgence of interest in psychedelic substances, the implications for tourist destinations, the therapeutic potential of psychedelics, and the associated health risks and ethical considerations.