2016
DOI: 10.1039/c6sm00250a
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Millimeter-area, free standing, phospholipid bilayers

Abstract: Minimal model biomembrane studies have the potential to unlock the fundamental mechanisms of cellular function that govern the processes upon which life relies. However, existing methods to fabricate free-standing model membranes currently have significant limitations. Bilayer sizes are often tens of micrometers, decoupling curvature or substrate effects, orthogonal control over tension, and solvent exchange combined with microscopy techniques is not possible, which restricts the studies that can be performed.… Show more

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Cited by 58 publications
(89 citation statements)
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“…The strongly self‐organized nature of the SMBs based on the asymmetric (πCore)‐C n molecules are in striking contrast to other SMBs, studied so far, composed of the biological lipids or synthetic amphiphiles . The latter SMBs are held together only by weak intermolecular interactions, and are known to exhibit internal lateral mobility of constituent molecules, similarly to the case of liquid crystals.…”
mentioning
confidence: 93%
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“…The strongly self‐organized nature of the SMBs based on the asymmetric (πCore)‐C n molecules are in striking contrast to other SMBs, studied so far, composed of the biological lipids or synthetic amphiphiles . The latter SMBs are held together only by weak intermolecular interactions, and are known to exhibit internal lateral mobility of constituent molecules, similarly to the case of liquid crystals.…”
mentioning
confidence: 93%
“…It is believed that the technique should be applicable to a wide variety of molecules composed of πCores substituted by alkyl chains. The uniformity, stability, and size scale are unprecedented, as compared to other artificial SMBs, as produced by other conventional self‐assembly processes . The obtained SMBs also afford TFTs showing excellent device characteristics exceeding those of amorphous Si TFTs.…”
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confidence: 96%
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“…Historically, vesicles and black lipid membranes were among the first suspended membranes to be successfully used. Over the years, many setups have been developed that provide multiple ways to form suspended membranes, e.g., on a hole between two separate compartments, at the tip of pipettes, between two emulsion droplets, on holey substrates, on nanodisks, and in microfabricated systems . Some of the other criteria are difficult to achieve with these suspended systems.…”
Section: Introductionmentioning
confidence: 99%
“…Over the years, many setups have been developed that provide multiple ways to form suspended membranes, e.g., on a hole between two separate compartments, [7,14] at the tip of pipettes, [8,9,15] between two emulsion droplets, [10] on holey substrates, [11,16] on nanodisks, [12,17,18] and in microfabricated systems. [19][20][21][22][23] Some of the other criteria are difficult to achieve with these suspended systems. One common difficulty is to recreate asymmetric bilayer.…”
Section: Introductionmentioning
confidence: 99%