2017
DOI: 10.1016/j.drudis.2016.11.012
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Mimicking the ocular environment for the study of inflammatory posterior eye disorders

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Cited by 7 publications
(2 citation statements)
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“…This work warrants future investigations, such as trialling LSF treatment in co-culture models of ARPE-19 and choroid-derived cells, and animal models of AMD. Performing high throughput transcriptomics methods will also help to identify key genes that mediate LSF’s effects on fatty acid and lipid metabolism, biosynthesis and translocation in RPE cells under AMD-like pathological conditions 56 . Other future experiments such Annexin V apoptosis detection and TNF-α assays that can demonstrate LSF’s protection against apoptosis and lipidomic response will also be beneficial.…”
Section: Discussionmentioning
confidence: 99%
“…This work warrants future investigations, such as trialling LSF treatment in co-culture models of ARPE-19 and choroid-derived cells, and animal models of AMD. Performing high throughput transcriptomics methods will also help to identify key genes that mediate LSF’s effects on fatty acid and lipid metabolism, biosynthesis and translocation in RPE cells under AMD-like pathological conditions 56 . Other future experiments such Annexin V apoptosis detection and TNF-α assays that can demonstrate LSF’s protection against apoptosis and lipidomic response will also be beneficial.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, many pathologies related to the posterior pole of the eye have been associated with these two processes, sharing their pathophysiology not only in oxidative stress but also in inflammation phenomena. Thus, ocular biomarkers associated with oxidative stress and inflammation represent a strategy in the diagnosis and monitoring of ocular diseases [ 4 , 23 ].…”
Section: Introductionmentioning
confidence: 99%